The effect of Beta glucan on Cisplatin ototoxicity
This study was undertaken to investigate the effect of betaglucan in ameliorating cisplatin ototoxicity. Rats were divided into four groups: cisplatin (C), cisplatin plus beta glucan (CB), beta glucan (B), and control (K). Distortion product otoacoustic emissions were elicited in 0th, 1st, and 5th days. For the group C differences were observed at 8,003 and 9,515 Hz between 0th and 5th days' measurements. In the group CB there were differences at frequencies of 3,996, 4,757, 5,660, and 6,726 Hz between 0th and 5th days' measurements. For the group B there were significant recovery in some frequencies. The observation of significant deterioration in terms of hearing in the group treated with cisplatin plus betaglucan may be suggested that depended on the increase of permeability and tissue conductance into the inner ear which may be caused by betaglucan. Further long-term follow-up studies by using different doses may clarify this matter.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2014 |
|---|---|
| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
|---|---|
| Enthalten in: |
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India - 66(2014), 2 vom: 20. Juni, Seite 131-4 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Bayindir, Tuba [VerfasserIn] |
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| Links: |
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| Themen: |
Betaglucan |
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| Anmerkungen: |
Date Completed 13.05.2014 Date Revised 21.10.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1007/s12070-013-0623-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM238194922 |
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| 245 | 1 | 4 | |a The effect of Beta glucan on Cisplatin ototoxicity |
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| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a This study was undertaken to investigate the effect of betaglucan in ameliorating cisplatin ototoxicity. Rats were divided into four groups: cisplatin (C), cisplatin plus beta glucan (CB), beta glucan (B), and control (K). Distortion product otoacoustic emissions were elicited in 0th, 1st, and 5th days. For the group C differences were observed at 8,003 and 9,515 Hz between 0th and 5th days' measurements. In the group CB there were differences at frequencies of 3,996, 4,757, 5,660, and 6,726 Hz between 0th and 5th days' measurements. For the group B there were significant recovery in some frequencies. The observation of significant deterioration in terms of hearing in the group treated with cisplatin plus betaglucan may be suggested that depended on the increase of permeability and tissue conductance into the inner ear which may be caused by betaglucan. Further long-term follow-up studies by using different doses may clarify this matter | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Betaglucan | |
| 650 | 4 | |a Cisplatin | |
| 650 | 4 | |a Otoacoustic emissions | |
| 650 | 4 | |a Ototoxicity | |
| 700 | 1 | |a Iraz, Mustafa |e verfasserin |4 aut | |
| 700 | 1 | |a Kelles, Mehmet |e verfasserin |4 aut | |
| 700 | 1 | |a Kaya, Serdar |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Mehmet |e verfasserin |4 aut | |
| 700 | 1 | |a Filiz, Aliye |e verfasserin |4 aut | |
| 700 | 1 | |a Toplu, Yuksel |e verfasserin |4 aut | |
| 700 | 1 | |a Kalcioglu, M Tayyar |e verfasserin |4 aut | |
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