Heterocyclic ring extension of androstenedione : synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives
Copyright © 2014 Elsevier Inc. All rights reserved..
The reaction of androstenedione with either malononitrile or ethyl cyanoacetate and aromatic aldehydes 2a-c gave the pyran derivatives 4a-f, respectively. On the other hand, the reaction of androstenedione with thiourea and the aromatic aldehydes 2a-c gave the pyrimidine derivatives 6a-c, respectively. Compound 6b reacted with 2-bromo-1-arylethanone derivatives 7a-d to give the indeno[2,1-e]thiazole derivatives 8a-d. Some of the produced compounds were used for further heterocyclization reactions. The cytotoxicity of the newly obtained products was evaluated against some cancer cell lines and a normal cell line.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
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| Enthalten in: |
Steroids - 86(2014) vom: 15. Aug., Seite 45-55 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mohareb, Rafat M [VerfasserIn] |
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| Links: |
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| Themen: |
409J2J96VR |
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| Anmerkungen: |
Date Completed 30.03.2015 Date Revised 19.06.2014 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.steroids.2014.04.011 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM237924021 |
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| 245 | 1 | 0 | |a Heterocyclic ring extension of androstenedione |b synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives |
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| 500 | |a Date Revised 19.06.2014 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2014 Elsevier Inc. All rights reserved. | ||
| 520 | |a The reaction of androstenedione with either malononitrile or ethyl cyanoacetate and aromatic aldehydes 2a-c gave the pyran derivatives 4a-f, respectively. On the other hand, the reaction of androstenedione with thiourea and the aromatic aldehydes 2a-c gave the pyrimidine derivatives 6a-c, respectively. Compound 6b reacted with 2-bromo-1-arylethanone derivatives 7a-d to give the indeno[2,1-e]thiazole derivatives 8a-d. Some of the produced compounds were used for further heterocyclization reactions. The cytotoxicity of the newly obtained products was evaluated against some cancer cell lines and a normal cell line | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Androstenedione | |
| 650 | 4 | |a Cytotoxicity | |
| 650 | 4 | |a Pyran | |
| 650 | 4 | |a Pyrimidine | |
| 650 | 4 | |a Thieno[2,3-b]pyridine | |
| 650 | 7 | |a Heterocyclic Compounds |2 NLM | |
| 650 | 7 | |a Pyrans |2 NLM | |
| 650 | 7 | |a Pyrimidines |2 NLM | |
| 650 | 7 | |a Thiazoles |2 NLM | |
| 650 | 7 | |a Androstenedione |2 NLM | |
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| 650 | 7 | |a pyrimidine |2 NLM | |
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| 700 | 1 | |a Abdelaziz, Mahmoud A |e verfasserin |4 aut | |
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