Studies on solvatomorphism of betulinic acid
© 2014 Wiley Periodicals, Inc. and the American Pharmacists Association..
Five solvates of betulinic acid with dimethyl sulfoxide (I), methanol (II), ethanol (III), isopropyl alcohol (IV), and 2-butanol (V) have been described in this work. Methods of X-ray crystallography, thermal analysis, and Fourier transform infrared spectroscopy were introduced for solvatomorphic identifications and characterizations. The orientation of isopropenyl and carboxylic groups might differ because of single-bonding rotations. The incorporation of solvents resulted in changes of the crystal symmetry, intermolecular arrangements, stoichiometry, hydrogen bonding interactions, and so on. Adducted solvents contributed most to the stability of crystal lattices and led to the formation of crystalline forms. Solvates II-V with their single-crystal structures determined have been reported for the first time.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:103 |
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| Enthalten in: |
Journal of pharmaceutical sciences - 103(2014), 9 vom: 14. Sept., Seite 2696-2703 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Xiaoying [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.05.2015 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jps.23853 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association. | ||
| 520 | |a Five solvates of betulinic acid with dimethyl sulfoxide (I), methanol (II), ethanol (III), isopropyl alcohol (IV), and 2-butanol (V) have been described in this work. Methods of X-ray crystallography, thermal analysis, and Fourier transform infrared spectroscopy were introduced for solvatomorphic identifications and characterizations. The orientation of isopropenyl and carboxylic groups might differ because of single-bonding rotations. The incorporation of solvents resulted in changes of the crystal symmetry, intermolecular arrangements, stoichiometry, hydrogen bonding interactions, and so on. Adducted solvents contributed most to the stability of crystal lattices and led to the formation of crystalline forms. Solvates II-V with their single-crystal structures determined have been reported for the first time | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a DSC | |
| 650 | 4 | |a FTIR | |
| 650 | 4 | |a XRPD | |
| 650 | 4 | |a betulinic acid | |
| 650 | 4 | |a crystal structure | |
| 650 | 4 | |a solvate | |
| 650 | 4 | |a solvatomorphism | |
| 650 | 4 | |a thermogravimetric analysis | |
| 650 | 7 | |a Pentacyclic Triterpenes |2 NLM | |
| 650 | 7 | |a Solvents |2 NLM | |
| 650 | 7 | |a Triterpenes |2 NLM | |
| 650 | 7 | |a Betulinic Acid |2 NLM | |
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| 700 | 1 | |a Gong, Ningbo |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Shiying |e verfasserin |4 aut | |
| 700 | 1 | |a Du, Guanhua |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Yang |e verfasserin |4 aut | |
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