Whole exome sequencing to estimate alloreactivity potential between donors and recipients in stem cell transplantation
© 2014 John Wiley & Sons Ltd..
Whole exome sequencing (WES) was performed on stem cell transplant donor-recipient (D-R) pairs to determine the extent of potential antigenic variation at a molecular level. In a small cohort of D-R pairs, a high frequency of sequence variation was observed between the donor and recipient exomes independent of human leucocyte antigen (HLA) matching. Nonsynonymous, nonconservative single nucleotide polymorphisms were approximately twice as frequent in HLA-matched unrelated, compared with related D-R pairs. When mapped to individual chromosomes, these polymorphic nucleotides were uniformly distributed across the entire exome. In conclusion, WES reveals extensive nucleotide sequence variation in the exomes of HLA-matched donors and recipients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:166 |
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| Enthalten in: |
British journal of haematology - 166(2014), 4 vom: 20. Aug., Seite 566-70 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sampson, Juliana K [VerfasserIn] |
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| Links: |
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| Themen: |
Alloreactivity potential |
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| Anmerkungen: |
Date Completed 18.09.2014 Date Revised 21.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/bjh.12898 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2014 John Wiley & Sons Ltd. | ||
| 520 | |a Whole exome sequencing (WES) was performed on stem cell transplant donor-recipient (D-R) pairs to determine the extent of potential antigenic variation at a molecular level. In a small cohort of D-R pairs, a high frequency of sequence variation was observed between the donor and recipient exomes independent of human leucocyte antigen (HLA) matching. Nonsynonymous, nonconservative single nucleotide polymorphisms were approximately twice as frequent in HLA-matched unrelated, compared with related D-R pairs. When mapped to individual chromosomes, these polymorphic nucleotides were uniformly distributed across the entire exome. In conclusion, WES reveals extensive nucleotide sequence variation in the exomes of HLA-matched donors and recipients | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a graft-versus-host disease | |
| 650 | 4 | |a single nucleotide polymorphism | |
| 650 | 4 | |a stem cell transplant | |
| 650 | 4 | |a whole exome sequencing | |
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| 700 | 1 | |a Koparde, Vishal N |e verfasserin |4 aut | |
| 700 | 1 | |a Scalora, Allison F |e verfasserin |4 aut | |
| 700 | 1 | |a Serrano, Myrna G |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Vladimir |e verfasserin |4 aut | |
| 700 | 1 | |a Roberts, Catherine H |e verfasserin |4 aut | |
| 700 | 1 | |a Jameson-Lee, Max |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira-Gonzalez, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Manjili, Masoud H |e verfasserin |4 aut | |
| 700 | 1 | |a Buck, Gregory A |e verfasserin |4 aut | |
| 700 | 1 | |a Neale, Michael C |e verfasserin |4 aut | |
| 700 | 1 | |a Toor, Amir A |e verfasserin |4 aut | |
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