Regulatory T cells, maternal-foetal immune tolerance and recurrent miscarriage : new therapeutic challenging opportunities
Copyright © 2014 Elsevier España, S.L.U. All rights reserved..
Because maternal alloreactive lymphocytes are not depleted during pregnancy, local and/or systemic mechanisms have to play a key role in altering the maternal immune response. Peripheral T regulatory cells (pTregs) at the maternal-foetal interface are necessary in situ to prevent early abortion, but only those pTregs that have been previously exposed to paternal alloantigens. It has been showed that pregnancy selectively stimulates the accumulation of maternal Foxp3(+)CD4(+)CD25(+) (Foxp3Tregs) cells with foetal specificity. Interestingly, after delivery, foetal-specific pTregs persist at elevated levels, maintain tolerance to pre-existing foetal antigen, and rapidly re-accumulate during subsequent pregnancy. pTreg up-regulation could be hypothesized as a possible future therapeutic strategy in humans.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:144 |
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| Enthalten in: |
Medicina clinica - 144(2015), 6 vom: 15. März, Seite 265-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alijotas-Reig, Jaume [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.12.2015 Date Revised 25.02.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.medcli.2014.01.033 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM236743031 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2014 Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a Because maternal alloreactive lymphocytes are not depleted during pregnancy, local and/or systemic mechanisms have to play a key role in altering the maternal immune response. Peripheral T regulatory cells (pTregs) at the maternal-foetal interface are necessary in situ to prevent early abortion, but only those pTregs that have been previously exposed to paternal alloantigens. It has been showed that pregnancy selectively stimulates the accumulation of maternal Foxp3(+)CD4(+)CD25(+) (Foxp3Tregs) cells with foetal specificity. Interestingly, after delivery, foetal-specific pTregs persist at elevated levels, maintain tolerance to pre-existing foetal antigen, and rapidly re-accumulate during subsequent pregnancy. pTreg up-regulation could be hypothesized as a possible future therapeutic strategy in humans | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Abortos recurrentes | |
| 650 | 4 | |a Citocinas | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Células NK/KIR | |
| 650 | 4 | |a Fracaso implantatorio | |
| 650 | 4 | |a Implantation failure | |
| 650 | 4 | |a Linfocitos T reguladores | |
| 650 | 4 | |a Maternal–foetal tolerance | |
| 650 | 4 | |a Miscarriages | |
| 650 | 4 | |a NK cells/KIR | |
| 650 | 4 | |a Regulatory-T lymphocytes | |
| 650 | 4 | |a Tolerancia maternofetal | |
| 650 | 4 | |a Tratamiento | |
| 650 | 4 | |a Treatment | |
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