Novel betacoronavirus in dromedaries of the Middle East, 2013
In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAE-HKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Emerging infectious diseases - 20(2014), 4 vom: 15. Apr., Seite 560-72 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Woo, Patrick C Y [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 16.12.2014 Date Revised 21.10.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.3201/eid2004.131769 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM236629778 |
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| 520 | |a In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAE-HKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a MERS-CoV | |
| 650 | 4 | |a Middle East | |
| 650 | 4 | |a Middle East respiratory syndrome coronavirus | |
| 650 | 4 | |a United Arab Emirates | |
| 650 | 4 | |a betacoronavirus | |
| 650 | 4 | |a camel | |
| 650 | 4 | |a camel coronavirus | |
| 650 | 4 | |a coronavirus | |
| 650 | 4 | |a dromedaries | |
| 650 | 4 | |a dromedary | |
| 650 | 4 | |a dromedary camel coronavirus UAE-HKU23 | |
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| 700 | 1 | |a Wernery, Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Emily Y M |e verfasserin |4 aut | |
| 700 | 1 | |a Tsang, Alan K L |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson, Bobby |e verfasserin |4 aut | |
| 700 | 1 | |a Yip, Cyril C Y |e verfasserin |4 aut | |
| 700 | 1 | |a Lau, Candy C Y |e verfasserin |4 aut | |
| 700 | 1 | |a Sivakumar, Saritha |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Jian-Piao |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Rachel Y Y |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Kwok-Hung |e verfasserin |4 aut | |
| 700 | 1 | |a Mareena, Ringu |e verfasserin |4 aut | |
| 700 | 1 | |a Yuen, Kwok-Yung |e verfasserin |4 aut | |
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