An electroactive biotin-doped polypyrrole substrate that immobilizes and releases EpCAM-positive cancer cells
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..
The specific capture and remotely controlled release of the EpCAM-positive cancer cells from biotin-doped polypyrrole (Ppy) films in response to an electrical potential is presented. As Ppy allows the direct incorporation of biotin molecules during the electrochemical process, densely packed biotin molecules can serve as the binding sites for streptavidin-tagged biomolecular complexes. This study demonstrates not only the enhanced capture and enrichment of EpCAM-positive cancer cells but also "on-demand" release of the viable cells from conductive Ppy in an electrical-potential-dependent way. This novel approach is of great importance in a diverse range of applications, and in particular in cancer diagnostics and screening.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Angewandte Chemie (International ed. in English) - 53(2014), 18 vom: 25. Apr., Seite 4597-602 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jeon, Seunghyun [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 16.04.2015 Date Revised 31.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/anie.201309998 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM236609416 |
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| 100 | 1 | |a Jeon, Seunghyun |e verfasserin |4 aut | |
| 245 | 1 | 3 | |a An electroactive biotin-doped polypyrrole substrate that immobilizes and releases EpCAM-positive cancer cells |
| 264 | 1 | |c 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 16.04.2015 | ||
| 500 | |a Date Revised 31.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | ||
| 520 | |a The specific capture and remotely controlled release of the EpCAM-positive cancer cells from biotin-doped polypyrrole (Ppy) films in response to an electrical potential is presented. As Ppy allows the direct incorporation of biotin molecules during the electrochemical process, densely packed biotin molecules can serve as the binding sites for streptavidin-tagged biomolecular complexes. This study demonstrates not only the enhanced capture and enrichment of EpCAM-positive cancer cells but also "on-demand" release of the viable cells from conductive Ppy in an electrical-potential-dependent way. This novel approach is of great importance in a diverse range of applications, and in particular in cancer diagnostics and screening | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a EpCAM | |
| 650 | 4 | |a HeLa cells | |
| 650 | 4 | |a MCF7 cells | |
| 650 | 4 | |a conducting polymers | |
| 650 | 4 | |a electrical stimulation | |
| 650 | 7 | |a Antigens, Neoplasm |2 NLM | |
| 650 | 7 | |a Cell Adhesion Molecules |2 NLM | |
| 650 | 7 | |a EPCAM protein, human |2 NLM | |
| 650 | 7 | |a Epithelial Cell Adhesion Molecule |2 NLM | |
| 650 | 7 | |a Polymers |2 NLM | |
| 650 | 7 | |a Pyrroles |2 NLM | |
| 650 | 7 | |a polypyrrole |2 NLM | |
| 650 | 7 | |a 30604-81-0 |2 NLM | |
| 650 | 7 | |a Biotin |2 NLM | |
| 650 | 7 | |a 6SO6U10H04 |2 NLM | |
| 650 | 7 | |a Streptavidin |2 NLM | |
| 650 | 7 | |a 9013-20-1 |2 NLM | |
| 700 | 1 | |a Moon, Jeong-Mi |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Eun Sook |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Yon Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Youngnam |e verfasserin |4 aut | |
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