Intravenous sodium nitrite in acute ST-elevation myocardial infarction : a randomized controlled trial (NIAMI)
© The Author 2014. Published by Oxford University Press on behalf of the European Society of Cardiology..
AIM: Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this double-blind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).
METHODS AND RESULTS: A total of 229 patients presenting with acute STEMI were randomized to receive either an i.v. infusion of 70 μmol sodium nitrite (n = 118) or matching placebo (n = 111) over 5 min immediately before primary percutaneous intervention (PPCI). Patients underwent cardiac magnetic resonance imaging (CMR) at 6-8 days and at 6 months and serial blood sampling was performed over 72 h for the measurement of plasma creatine kinase (CK) and Troponin I. Myocardial infarct size (extent of late gadolinium enhancement at 6-8 days by CMR-the primary endpoint) did not differ between nitrite and placebo groups after adjustment for area at risk, diabetes status, and centre (effect size -0.7% 95% CI: -2.2%, +0.7%; P = 0.34). There were no significant differences in any of the secondary endpoints, including plasma troponin I and CK area under the curve, left ventricular volumes (LV), and ejection fraction (EF) measured at 6-8 days and at 6 months and final infarct size (FIS) measured at 6 months.
CONCLUSIONS: Sodium nitrite administered intravenously immediately prior to reperfusion in patients with acute STEMI does not reduce infarct size.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2014 |
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Erschienen: |
2014 |
Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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Enthalten in: |
European heart journal - 35(2014), 19 vom: 14. Mai, Seite 1255-62 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Siddiqi, Nishat [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 29.12.2014 Date Revised 29.01.2022 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1093/eurheartj/ehu096 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM236487795 |
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245 | 1 | 0 | |a Intravenous sodium nitrite in acute ST-elevation myocardial infarction |b a randomized controlled trial (NIAMI) |
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500 | |a Citation Status MEDLINE | ||
520 | |a © The Author 2014. Published by Oxford University Press on behalf of the European Society of Cardiology. | ||
520 | |a AIM: Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this double-blind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI) | ||
520 | |a METHODS AND RESULTS: A total of 229 patients presenting with acute STEMI were randomized to receive either an i.v. infusion of 70 μmol sodium nitrite (n = 118) or matching placebo (n = 111) over 5 min immediately before primary percutaneous intervention (PPCI). Patients underwent cardiac magnetic resonance imaging (CMR) at 6-8 days and at 6 months and serial blood sampling was performed over 72 h for the measurement of plasma creatine kinase (CK) and Troponin I. Myocardial infarct size (extent of late gadolinium enhancement at 6-8 days by CMR-the primary endpoint) did not differ between nitrite and placebo groups after adjustment for area at risk, diabetes status, and centre (effect size -0.7% 95% CI: -2.2%, +0.7%; P = 0.34). There were no significant differences in any of the secondary endpoints, including plasma troponin I and CK area under the curve, left ventricular volumes (LV), and ejection fraction (EF) measured at 6-8 days and at 6 months and final infarct size (FIS) measured at 6 months | ||
520 | |a CONCLUSIONS: Sodium nitrite administered intravenously immediately prior to reperfusion in patients with acute STEMI does not reduce infarct size | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Multicenter Study | |
650 | 4 | |a Randomized Controlled Trial | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Acute myocardial infarction | |
650 | 4 | |a Cardioprotection | |
650 | 4 | |a Ischaemia-reperfusion injury | |
650 | 4 | |a Nitrite | |
650 | 7 | |a Biomarkers |2 NLM | |
650 | 7 | |a Cardiotonic Agents |2 NLM | |
650 | 7 | |a Sodium Nitrite |2 NLM | |
650 | 7 | |a M0KG633D4F |2 NLM | |
700 | 1 | |a Neil, Christopher |e verfasserin |4 aut | |
700 | 1 | |a Bruce, Margaret |e verfasserin |4 aut | |
700 | 1 | |a MacLennan, Graeme |e verfasserin |4 aut | |
700 | 1 | |a Cotton, Seonaidh |e verfasserin |4 aut | |
700 | 1 | |a Papadopoulou, Sofia |e verfasserin |4 aut | |
700 | 1 | |a Feelisch, Martin |e verfasserin |4 aut | |
700 | 1 | |a Bunce, Nicholas |e verfasserin |4 aut | |
700 | 1 | |a Lim, Pitt O |e verfasserin |4 aut | |
700 | 1 | |a Hildick-Smith, David |e verfasserin |4 aut | |
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700 | 1 | |a Madhani, Melanie |e verfasserin |4 aut | |
700 | 1 | |a Boon, Nicholas |e verfasserin |4 aut | |
700 | 1 | |a Dawson, Dana |e verfasserin |4 aut | |
700 | 1 | |a Kaski, Juan Carlos |e verfasserin |4 aut | |
700 | 1 | |a Frenneaux, Michael |e verfasserin |4 aut | |
700 | 0 | |a NIAMI investigators |e verfasserin |4 aut | |
700 | 1 | |a Siddiqi, Nishat |e investigator |4 oth | |
700 | 1 | |a Neil, Christopher |e investigator |4 oth | |
700 | 1 | |a Bruce, Margaret |e investigator |4 oth | |
700 | 1 | |a MacLennan, Graeme |e investigator |4 oth | |
700 | 1 | |a Cotton, Seonaidh |e investigator |4 oth | |
700 | 1 | |a Dawson, Dana |e investigator |4 oth | |
700 | 1 | |a Frenneaux, Michael |e investigator |4 oth | |
700 | 1 | |a Singh, Satnam |e investigator |4 oth | |
700 | 1 | |a Schwarz, Konstantin |e investigator |4 oth | |
700 | 1 | |a Jagpal, Baljit |e investigator |4 oth | |
700 | 1 | |a Metcalfe, Malcolm |e investigator |4 oth | |
700 | 1 | |a Stewart, Andrew |e investigator |4 oth | |
700 | 1 | |a Hannah, Andrew |e investigator |4 oth | |
700 | 1 | |a Awsan, Noman |e investigator |4 oth | |
700 | 1 | |a Broadhurst, Paul |e investigator |4 oth | |
700 | 1 | |a Hogg, Duncan |e investigator |4 oth | |
700 | 1 | |a Garg, Deepak |e investigator |4 oth | |
700 | 1 | |a Slattery, Elaine |e investigator |4 oth | |
700 | 1 | |a Davidson, Tracey |e investigator |4 oth | |
700 | 1 | |a McDonald, Alison |e investigator |4 oth | |
700 | 1 | |a McPherson, Gladys |e investigator |4 oth | |
700 | 1 | |a Kaski, Juan-Carlos |e investigator |4 oth | |
700 | 1 | |a Lim, Pitt O |e investigator |4 oth | |
700 | 1 | |a Brown, Sue |e investigator |4 oth | |
700 | 1 | |a Papadopoulou, Sofia A |e investigator |4 oth | |
700 | 1 | |a Gonzalvez, Fatima |e investigator |4 oth | |
700 | 1 | |a Roy, David |e investigator |4 oth | |
700 | 1 | |a Firoozi, Sami |e investigator |4 oth | |
700 | 1 | |a Bogle, Richard |e investigator |4 oth | |
700 | 1 | |a Roberts, Elved |e investigator |4 oth | |
700 | 1 | |a Rhodes, Jonathan |e investigator |4 oth | |
700 | 1 | |a Hildick-Smith, David |e investigator |4 oth | |
700 | 1 | |a de Belder, Adam |e investigator |4 oth | |
700 | 1 | |a Cooter, Nina |e investigator |4 oth | |
700 | 1 | |a Bennett, Lorraine |e investigator |4 oth | |
700 | 1 | |a Horowitz, John |e investigator |4 oth | |
700 | 1 | |a Rajendran, Sharmalar |e investigator |4 oth | |
700 | 1 | |a Dautov, Rustem |e investigator |4 oth | |
700 | 1 | |a Black, Marilyn |e investigator |4 oth | |
700 | 1 | |a Jansen, Else |e investigator |4 oth | |
700 | 1 | |a Boon, Nicholas |e investigator |4 oth | |
700 | 1 | |a Struthers, Allan |e investigator |4 oth | |
700 | 1 | |a Toff, William |e investigator |4 oth | |
700 | 1 | |a Dargie, Henry |e investigator |4 oth | |
700 | 1 | |a Lang, Chim |e investigator |4 oth | |
700 | 1 | |a Nightingale, Peter |e investigator |4 oth | |
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