Prevalence of subclinical atheromatosis and associated risk factors in chronic kidney disease : the NEFRONA study
© The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved..
BACKGROUND: The causes of the high cardiovascular mortality observed in chronic kidney disease (CKD) are unknown. Here, we report data on prevalence of subclinical atherosclerosis in the NEFRONA population and a stratified multivariate logistic analysis of factors associated with the presence of plaque.
METHODS: We analysed 2445 patients with an estimated glomerular filtration rate (eGFR) <60 mL/min (CKD 3: 937; CKD 4-5: 820; CKD 5D: 688) and 559 non-CKD subjects (eGFR >60 mL/min), 18-75 years old, without previous cardiovascular events. An itinerant team of professionals performed carotid and femoral arterial ultrasound.
RESULTS: The already high prevalence of plaques in CKD 3 is even higher in more severe CKD. Multivariate logistic analysis showed that, at any CKD stage, age and being male are independently associated with the presence of plaques. In CKD 3, there was a significant interaction of the smoking status and triglycerides levels which were independently associated with the presence of plaque. Furthermore, being diabetic was also associated with the presence of subclinical atherosclerosis. In stage 4-5 there was a significant association with smoking, high phosphate and hsCRP levels. In dialysis patients, being diabetic, having low levels of 25(OH)-vitamin D3 and smoking status also showed a significant association with the presence of plaque. Furthermore, the association of phosphate levels with the presence of subclinical atheromatosis showed a U-shaped curve.
CONCLUSIONS: This analysis demonstrates the magnitude of subclinical atheromatous disease in a large CKD population. The patient characteristics associated with the presence of plaque differ in every CKD stage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 29(2014), 7 vom: 11. Juli, Seite 1415-22 |
| Sprache: |
Englisch |
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| Links: |
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| Themen: |
Atheromatosis |
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| Anmerkungen: |
Date Completed 23.09.2014 Date Revised 18.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1093/ndt/gfu038 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM236002325 |
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| 024 | 7 | |a 10.1093/ndt/gfu038 |2 doi | |
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| 041 | |a eng | ||
| 100 | 1 | |a Betriu, Angels |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prevalence of subclinical atheromatosis and associated risk factors in chronic kidney disease |b the NEFRONA study |
| 264 | 1 | |c 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.09.2014 | ||
| 500 | |a Date Revised 18.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. | ||
| 520 | |a BACKGROUND: The causes of the high cardiovascular mortality observed in chronic kidney disease (CKD) are unknown. Here, we report data on prevalence of subclinical atherosclerosis in the NEFRONA population and a stratified multivariate logistic analysis of factors associated with the presence of plaque | ||
| 520 | |a METHODS: We analysed 2445 patients with an estimated glomerular filtration rate (eGFR) <60 mL/min (CKD 3: 937; CKD 4-5: 820; CKD 5D: 688) and 559 non-CKD subjects (eGFR >60 mL/min), 18-75 years old, without previous cardiovascular events. An itinerant team of professionals performed carotid and femoral arterial ultrasound | ||
| 520 | |a RESULTS: The already high prevalence of plaques in CKD 3 is even higher in more severe CKD. Multivariate logistic analysis showed that, at any CKD stage, age and being male are independently associated with the presence of plaques. In CKD 3, there was a significant interaction of the smoking status and triglycerides levels which were independently associated with the presence of plaque. Furthermore, being diabetic was also associated with the presence of subclinical atherosclerosis. In stage 4-5 there was a significant association with smoking, high phosphate and hsCRP levels. In dialysis patients, being diabetic, having low levels of 25(OH)-vitamin D3 and smoking status also showed a significant association with the presence of plaque. Furthermore, the association of phosphate levels with the presence of subclinical atheromatosis showed a U-shaped curve | ||
| 520 | |a CONCLUSIONS: This analysis demonstrates the magnitude of subclinical atheromatous disease in a large CKD population. The patient characteristics associated with the presence of plaque differ in every CKD stage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a atheromatosis | |
| 650 | 4 | |a cardiovascular disease prevention | |
| 650 | 4 | |a chronic kidney disease | |
| 650 | 4 | |a subclinical | |
| 650 | 4 | |a ultrasound | |
| 700 | 1 | |a Martinez-Alonso, Montserrat |e verfasserin |4 aut | |
| 700 | 1 | |a Arcidiacono, Maria Vittoria |e verfasserin |4 aut | |
| 700 | 1 | |a Cannata-Andia, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Pascual, Julio |e verfasserin |4 aut | |
| 700 | 1 | |a Valdivielso, José Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández, Elvira |e verfasserin |4 aut | |
| 700 | 0 | |a Investigators from the NEFRONA Study |e verfasserin |4 aut | |
| 700 | 1 | |a Aladrén Regidor, M José |e investigator |4 oth | |
| 700 | 1 | |a Almirall, Jaume |e investigator |4 oth | |
| 700 | 1 | |a Ponz, Esther |e investigator |4 oth | |
| 700 | 1 | |a Arteaga Coloma, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Bajo Rubio, M Auxiliadora |e investigator |4 oth | |
| 700 | 1 | |a Belart Rodríguez, Montse |e investigator |4 oth | |
| 700 | 1 | |a Bielsa-García, Sara |e investigator |4 oth | |
| 700 | 1 | |a Bover Sanjuan, Jordi |e investigator |4 oth | |
| 700 | 1 | |a Bronsoms Artero, Josep |e investigator |4 oth | |
| 700 | 1 | |a Cabezuelo Romero, Juan B |e investigator |4 oth | |
| 700 | 1 | |a Muray Cases, Salomé |e investigator |4 oth | |
| 700 | 1 | |a Calviño Varela, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Caro Acevedo, Pilar |e investigator |4 oth | |
| 700 | 1 | |a Carreras Bassa, Jordi |e investigator |4 oth | |
| 700 | 1 | |a Cases Amenós, Aleix |e investigator |4 oth | |
| 700 | 1 | |a Massó Jiménez, Elisabet |e investigator |4 oth | |
| 700 | 1 | |a Castilla Pérez, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Cigarrán Guldris, Secundino |e investigator |4 oth | |
| 700 | 1 | |a López Prieto, Saray |e investigator |4 oth | |
| 700 | 1 | |a Comas Mongay, Lurdes |e investigator |4 oth | |
| 700 | 1 | |a Comerma, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Compte Jové, M Teresa |e investigator |4 oth | |
| 700 | 1 | |a Cuberes Izquierdo, Marta |e investigator |4 oth | |
| 700 | 1 | |a de álvaro, Fernando |e investigator |4 oth | |
| 700 | 1 | |a Hevia Ojanguren, Covadonga |e investigator |4 oth | |
| 700 | 1 | |a de Arriba de la Fuente, Gabriel |e investigator |4 oth | |
| 700 | 1 | |a del Pino y Pino, Maria Dolores |e investigator |4 oth | |
| 700 | 1 | |a Diaz-Tejeiro Izquierdo, Rafael |e investigator |4 oth | |
| 700 | 1 | |a Dotori, Marta |e investigator |4 oth | |
| 700 | 1 | |a Duarte, Verónica |e investigator |4 oth | |
| 700 | 1 | |a Estupiñan Torres, Sara |e investigator |4 oth | |
| 700 | 1 | |a Fernández Reyes, María José |e investigator |4 oth | |
| 700 | 1 | |a Fernández Rodríguez, Maria Loreto |e investigator |4 oth | |
| 700 | 1 | |a Fernández, Guillermina |e investigator |4 oth | |
| 700 | 1 | |a Galán Serrano, Antonio |e investigator |4 oth | |
| 700 | 1 | |a García Cantón, Cesar |e investigator |4 oth | |
| 700 | 1 | |a García Herrera, Antonio L |e investigator |4 oth | |
| 700 | 1 | |a García Mena, Mercedes |e investigator |4 oth | |
| 700 | 1 | |a Gil Sacaluga, Luis |e investigator |4 oth | |
| 700 | 1 | |a Aguilar, Maria |e investigator |4 oth | |
| 700 | 1 | |a Gorriz, José Luis |e investigator |4 oth | |
| 700 | 1 | |a Huarte Loza, Emma |e investigator |4 oth | |
| 700 | 1 | |a Lerma, José Luis |e investigator |4 oth | |
| 700 | 1 | |a Liebana Cañada, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Marín Álvarezro, Jesús Pedro |e investigator |4 oth | |
| 700 | 1 | |a Martín Alemany, Nàdia |e investigator |4 oth | |
| 700 | 1 | |a Martín Garcia, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Martínez Castelao, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Martínez Villaescusa, María |e investigator |4 oth | |
| 700 | 1 | |a Martínez, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Moreno Los Huertos, Silvia |e investigator |4 oth | |
| 700 | 1 | |a Mouzo Mirco, Ricardo |e investigator |4 oth | |
| 700 | 1 | |a Munar Vila, Antonia |e investigator |4 oth | |
| 700 | 1 | |a Muñoz Díaz, Ana Beatriz |e investigator |4 oth | |
| 700 | 1 | |a Navarro González, Juan F |e investigator |4 oth | |
| 700 | 1 | |a Nieto, Javier |e investigator |4 oth | |
| 700 | 1 | |a Carreño, Agustín |e investigator |4 oth | |
| 700 | 1 | |a Novoa Fernández, Enrique |e investigator |4 oth | |
| 700 | 1 | |a Ortiz, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Fernandez, Beatriz |e investigator |4 oth | |
| 700 | 1 | |a Paraíso, Vicente |e investigator |4 oth | |
| 700 | 1 | |a Pérez Fontán, Miguel |e investigator |4 oth | |
| 700 | 1 | |a Peris Domingo, Ana |e investigator |4 oth | |
| 700 | 1 | |a Piñera Haces, Celestino |e investigator |4 oth | |
| 700 | 1 | |a Prados Garrido, Maria Dolores |e investigator |4 oth | |
| 700 | 1 | |a Prieto Velasco, Mario |e investigator |4 oth | |
| 700 | 1 | |a Puig Marí, Carmina |e investigator |4 oth | |
| 700 | 1 | |a Rivera Gorrín, Maite |e investigator |4 oth | |
| 700 | 1 | |a Rubio, Esther |e investigator |4 oth | |
| 700 | 1 | |a Ruiz, Pilar |e investigator |4 oth | |
| 700 | 1 | |a Salgueira Lazo, Mercedes |e investigator |4 oth | |
| 700 | 1 | |a Martínez Puerto, Ana Isabel |e investigator |4 oth | |
| 700 | 1 | |a Sánchez Tomero, José Antonio |e investigator |4 oth | |
| 700 | 1 | |a Sánchez, José Emilio |e investigator |4 oth | |
| 700 | 1 | |a Sans Lorman, Ramon |e investigator |4 oth | |
| 700 | 1 | |a Saracho, Ramon |e investigator |4 oth | |
| 700 | 1 | |a Sarrias, Maria |e investigator |4 oth | |
| 700 | 1 | |a Prat, Oreto |e investigator |4 oth | |
| 700 | 1 | |a Soler, Maríra José |e investigator |4 oth | |
| 700 | 1 | |a Barrios, Clara |e investigator |4 oth | |
| 700 | 1 | |a Sousa, Fernando |e investigator |4 oth | |
| 700 | 1 | |a Toran, Daniel |e investigator |4 oth | |
| 700 | 1 | |a Tornero Molina, Fernando |e investigator |4 oth | |
| 700 | 1 | |a Usón Carrasco, José Javier |e investigator |4 oth | |
| 700 | 1 | |a Valera Cortes, Ildefonso |e investigator |4 oth | |
| 700 | 1 | |a Vilaprinyo del Perugia, M Merce |e investigator |4 oth | |
| 700 | 1 | |a Virto Ruiz, Rafael C |e investigator |4 oth | |
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