Experience with selenium used to recover adrenocortical function in patients taking glucocorticosteroids long
AIM: To study the effect of selenium on adrenocortical function in patients taking glucocorticosteroids (GCS) long.
SUBJECTS AND METHODS: The study included 56 patients who had been long taking oral GCS for the underlying disease. Adrenocortical function was evaluated by a short synacthen test; adrenal insufficiency (mean cortisol level 8.2 microg/dl) was identified in 52 patients. A study group of patients (n = 35) was given selenium 200 microg/day. A control group (n = 17) with the detected adrenal insufficiency did not take it. All the patients (n = 52) continued to receive standard therapy for the underlying disease, including oral GCS.
RESULTS: Adrenal function was reexamined 6 months later; the two paired-samples t-test indicated a statistically significant increase in cortisol levels up to 23.20 +/- 4.2 microg/dl (p < or = 0.05) in the patient group receiving selenium in addition to the basic therapy. In the control group, the function did not recover (cortisol levels were 8.6 and 9.8 microg/dl at baseline and at 6 months, respectively; p < or = 0.05).
CONCLUSION: The experience with selenium 200 microg/day given long to patients with adrenal insufficiency caused by the long-term use of GCS shows that the agent is effective in recovering adrenocortical function.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:85 |
|---|---|
| Enthalten in: |
Terapevticheskii arkhiv - 85(2013), 10 vom: 02., Seite 76-8 |
| Sprache: |
Russisch |
|---|
| Beteiligte Personen: |
Voĭtsekhovskaia, Iu G [VerfasserIn] |
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| Themen: |
Antioxidants |
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| Anmerkungen: |
Date Completed 11.02.2014 Date Revised 20.01.2014 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM234600128 |
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| 245 | 1 | 0 | |a Experience with selenium used to recover adrenocortical function in patients taking glucocorticosteroids long |
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| 500 | |a Date Revised 20.01.2014 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: To study the effect of selenium on adrenocortical function in patients taking glucocorticosteroids (GCS) long | ||
| 520 | |a SUBJECTS AND METHODS: The study included 56 patients who had been long taking oral GCS for the underlying disease. Adrenocortical function was evaluated by a short synacthen test; adrenal insufficiency (mean cortisol level 8.2 microg/dl) was identified in 52 patients. A study group of patients (n = 35) was given selenium 200 microg/day. A control group (n = 17) with the detected adrenal insufficiency did not take it. All the patients (n = 52) continued to receive standard therapy for the underlying disease, including oral GCS | ||
| 520 | |a RESULTS: Adrenal function was reexamined 6 months later; the two paired-samples t-test indicated a statistically significant increase in cortisol levels up to 23.20 +/- 4.2 microg/dl (p < or = 0.05) in the patient group receiving selenium in addition to the basic therapy. In the control group, the function did not recover (cortisol levels were 8.6 and 9.8 microg/dl at baseline and at 6 months, respectively; p < or = 0.05) | ||
| 520 | |a CONCLUSION: The experience with selenium 200 microg/day given long to patients with adrenal insufficiency caused by the long-term use of GCS shows that the agent is effective in recovering adrenocortical function | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Glucocorticoids |2 NLM | |
| 650 | 7 | |a Selenium |2 NLM | |
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| 700 | 1 | |a Voskresenskaia, N |e verfasserin |4 aut | |
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| 700 | 1 | |a Ivanov, I V |e verfasserin |4 aut | |
| 700 | 1 | |a Gredzena, P |e verfasserin |4 aut | |
| 700 | 1 | |a Karpov, Iu G |e verfasserin |4 aut | |
| 700 | 1 | |a Ianovskaia, Ia |e verfasserin |4 aut | |
| 700 | 1 | |a Voĭtsekhovskiĭ, V V |e verfasserin |4 aut | |
| 700 | 1 | |a Maulinysh, E |e verfasserin |4 aut | |
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