Risk factors for mortality in patients with invasive mucormycosis
BACKGROUND: Mucormycosis is an uncommon and life-threatening fungal infection. The clinical predictors of outcome were evaluated in patients with invasive mucormycosis.
MATERIALS AND METHODS: We retrospectively reviewed histologically proven cases of invasive mucormycosis in our institution from 1996 to 2012.
RESULTS: A total of 64 patients were analyzed. The median age was 59 years (interquartile range [IQR], 50-67), and 32 patients (50%) were male. The most common underlying diseases were diabetes mellitus (67%), hematologic malignancy (22%), and solid cancer (19%). The most common infection sites were the rhino-orbito-cerebral area (56%) and the lungs (31%). The 180-day all-cause mortality was 33%. Disseminated infection was associated with increased mortality (hazard ratio [HR]: 169.74, 95% confidence interval [CI]: 6.41 to 4492.64; P = 0.002). Pulmonary infection (HR: 0.08, 95% CI: 0.01 to 0.66; P = 0.02) and complete surgical removal of infected tissue (HR: 0.12, 95% CI: 0.02 to 0.64; P = 0.01) were associated with decreased mortality.
CONCLUSIONS: These results suggest that patients with mucormycosis had a lower risk of mortality if they developed a pulmonary infection, rather than a disseminated infection and with complete debridement of infected tissue.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2013 |
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Erschienen: |
2013 |
Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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Enthalten in: |
Infection & chemotherapy - 45(2013), 3 vom: 11. Sept., Seite 292-8 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Hong, Hyo-Lim [VerfasserIn] |
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Links: |
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Themen: |
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Anmerkungen: |
Date Completed 07.01.2014 Date Revised 21.10.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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doi: |
10.3947/ic.2013.45.3.292 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM234220147 |
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520 | |a BACKGROUND: Mucormycosis is an uncommon and life-threatening fungal infection. The clinical predictors of outcome were evaluated in patients with invasive mucormycosis | ||
520 | |a MATERIALS AND METHODS: We retrospectively reviewed histologically proven cases of invasive mucormycosis in our institution from 1996 to 2012 | ||
520 | |a RESULTS: A total of 64 patients were analyzed. The median age was 59 years (interquartile range [IQR], 50-67), and 32 patients (50%) were male. The most common underlying diseases were diabetes mellitus (67%), hematologic malignancy (22%), and solid cancer (19%). The most common infection sites were the rhino-orbito-cerebral area (56%) and the lungs (31%). The 180-day all-cause mortality was 33%. Disseminated infection was associated with increased mortality (hazard ratio [HR]: 169.74, 95% confidence interval [CI]: 6.41 to 4492.64; P = 0.002). Pulmonary infection (HR: 0.08, 95% CI: 0.01 to 0.66; P = 0.02) and complete surgical removal of infected tissue (HR: 0.12, 95% CI: 0.02 to 0.64; P = 0.01) were associated with decreased mortality | ||
520 | |a CONCLUSIONS: These results suggest that patients with mucormycosis had a lower risk of mortality if they developed a pulmonary infection, rather than a disseminated infection and with complete debridement of infected tissue | ||
650 | 4 | |a Journal Article | |
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