Clinical significance of serum triple monoclonal components : a report of 6 cases and a review of the literature
Copyright © 2013 Elsevier Ltd. All rights reserved..
A serum multiple monoclonal component (MC) is very rare. We here report 6 patients with 3 MCs. The triple MC was detected in all of them by immunofixation. 2/6 patients did not present hematological or oncological associated disease, while in the remaining 4, Waldenström macroglobulinaemia (2 cases), Polycythemia Vera and non-Hodgkin lymphoma were diagnosed. Of the 49 global patients reported in the literature (6+43), 64.6% had a lymphoproliferative disorder and only in 3 cases there was no associated disease. Therefore, the detection of such laboratory evidence should propel physicians to a deeper investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
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| Enthalten in: |
Leukemia research - 38(2014), 2 vom: 31. Feb., Seite 166-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guastafierro, Salvatore [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 17.03.2014 Date Revised 21.01.2014 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.leukres.2013.10.020 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM233447377 |
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| 100 | 1 | |a Guastafierro, Salvatore |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical significance of serum triple monoclonal components |b a report of 6 cases and a review of the literature |
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| 500 | |a Date Revised 21.01.2014 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2013 Elsevier Ltd. All rights reserved. | ||
| 520 | |a A serum multiple monoclonal component (MC) is very rare. We here report 6 patients with 3 MCs. The triple MC was detected in all of them by immunofixation. 2/6 patients did not present hematological or oncological associated disease, while in the remaining 4, Waldenström macroglobulinaemia (2 cases), Polycythemia Vera and non-Hodgkin lymphoma were diagnosed. Of the 49 global patients reported in the literature (6+43), 64.6% had a lymphoproliferative disorder and only in 3 cases there was no associated disease. Therefore, the detection of such laboratory evidence should propel physicians to a deeper investigation | ||
| 650 | 4 | |a Case Reports | |
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| 650 | 4 | |a Immunofixation | |
| 650 | 4 | |a Intracellular immunofluorescence | |
| 650 | 4 | |a Lymphoproliferative disorders | |
| 650 | 4 | |a Serum electrophoresis | |
| 650 | 4 | |a Triple monoclonal component | |
| 650 | 7 | |a Antibodies, Monoclonal |2 NLM | |
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| 700 | 1 | |a Parascandola, Rita Rosaria |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrara, Maria Giovanna |e verfasserin |4 aut | |
| 700 | 1 | |a Di Martino, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Pezone, Luciano |e verfasserin |4 aut | |
| 700 | 1 | |a Falcone, Umberto |e verfasserin |4 aut | |
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