Progression of attachment loss is strongly associated with presence of the JP2 genotype of Aggregatibacter actinomycetemcomitans : a prospective cohort study of a young adolescent population
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
AIM: To assess the progression of attachment loss (AL) during a 2-year period according to the presence of JP2 and non-JP2 genotypes of Aggregatibacter actinomycetemcomitans in a Ghanaian adolescent population.
METHODS: A total of 500 adolescents (mean age 13.2 years, SD ± 1.5) were enrolled in the study. After 2 years, 397 (79.4%) returned for a periodontal re-examination, including the measurement of AL. The carrier status of the JP2 and non-JP2 genotypes of A. actinomycetemcomitans was evaluated in a baseline examination 2 years earlier.
RESULTS: Individuals who carried the JP2 genotype of A. actinomycetemcomitans had a significantly increased risk [relative risk (RR) = 7.3] of developing AL ≥ 3 mm. The mean AL at the follow-up and the mean 2-year progression of AL were significantly higher in the JP2 genotype-positive group (n = 38) compared with the group positive for the non-JP2 genotypes of A. actinomycetemcomitans (n = 169), and the group of A. actinomycetemcomitans-negative individuals (n = 190). The JP2 genotype was strongly associated with the progression of AL ≥ 3 mm (OR = 14.3). The non-JP2 genotypes of A. actinomycetemcomitans were also, however, less pronounced, associated with the progression of AL ≥ 3 mm (OR = 3.4).
CONCLUSION: The JP2 genotype of A. actinomycetemcomitans is strongly associated with the progression of AL.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2014 |
|---|---|
| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
|---|---|
| Enthalten in: |
Journal of clinical periodontology - 41(2014), 3 vom: 26. März, Seite 232-41 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Höglund Åberg, Carola [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 05.12.2014 Date Revised 05.02.2014 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/jcpe.12209 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM233337229 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM233337229 | ||
| 003 | DE-627 | ||
| 005 | 20231224094908.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/jcpe.12209 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0777.xml |
| 035 | |a (DE-627)NLM233337229 | ||
| 035 | |a (NLM)24304011 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Höglund Åberg, Carola |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Progression of attachment loss is strongly associated with presence of the JP2 genotype of Aggregatibacter actinomycetemcomitans |b a prospective cohort study of a young adolescent population |
| 264 | 1 | |c 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.12.2014 | ||
| 500 | |a Date Revised 05.02.2014 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | ||
| 520 | |a AIM: To assess the progression of attachment loss (AL) during a 2-year period according to the presence of JP2 and non-JP2 genotypes of Aggregatibacter actinomycetemcomitans in a Ghanaian adolescent population | ||
| 520 | |a METHODS: A total of 500 adolescents (mean age 13.2 years, SD ± 1.5) were enrolled in the study. After 2 years, 397 (79.4%) returned for a periodontal re-examination, including the measurement of AL. The carrier status of the JP2 and non-JP2 genotypes of A. actinomycetemcomitans was evaluated in a baseline examination 2 years earlier | ||
| 520 | |a RESULTS: Individuals who carried the JP2 genotype of A. actinomycetemcomitans had a significantly increased risk [relative risk (RR) = 7.3] of developing AL ≥ 3 mm. The mean AL at the follow-up and the mean 2-year progression of AL were significantly higher in the JP2 genotype-positive group (n = 38) compared with the group positive for the non-JP2 genotypes of A. actinomycetemcomitans (n = 169), and the group of A. actinomycetemcomitans-negative individuals (n = 190). The JP2 genotype was strongly associated with the progression of AL ≥ 3 mm (OR = 14.3). The non-JP2 genotypes of A. actinomycetemcomitans were also, however, less pronounced, associated with the progression of AL ≥ 3 mm (OR = 3.4) | ||
| 520 | |a CONCLUSION: The JP2 genotype of A. actinomycetemcomitans is strongly associated with the progression of AL | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a A. actinomycetemcomitans | |
| 650 | 4 | |a Ghana | |
| 650 | 4 | |a JP2 genotype | |
| 650 | 4 | |a adolescent | |
| 650 | 4 | |a attachment loss | |
| 650 | 4 | |a leukotoxin | |
| 650 | 4 | |a periodontitis | |
| 650 | 4 | |a progression | |
| 650 | 7 | |a Bacterial Toxins |2 NLM | |
| 650 | 7 | |a Cytotoxins |2 NLM | |
| 650 | 7 | |a Exotoxins |2 NLM | |
| 650 | 7 | |a Virulence Factors |2 NLM | |
| 650 | 7 | |a leukotoxin |2 NLM | |
| 700 | 1 | |a Kwamin, Francis |e verfasserin |4 aut | |
| 700 | 1 | |a Claesson, Rolf |e verfasserin |4 aut | |
| 700 | 1 | |a Dahlén, Gunnar |e verfasserin |4 aut | |
| 700 | 1 | |a Johansson, Anders |e verfasserin |4 aut | |
| 700 | 1 | |a Haubek, Dorte |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of clinical periodontology |d 1974 |g 41(2014), 3 vom: 26. März, Seite 232-41 |w (DE-627)NLM000276847 |x 1600-051X |7 nnns |
| 773 | 1 | 8 | |g volume:41 |g year:2014 |g number:3 |g day:26 |g month:03 |g pages:232-41 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/jcpe.12209 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 41 |j 2014 |e 3 |b 26 |c 03 |h 232-41 | ||