Glucocorticoids and foetal heart maturation; implications for prematurity and foetal programming
Glucocorticoids are steroid hormones, essential in mammals to prepare for life after birth. Blood levels of glucocorticoids (cortisol in most mammals including humans; corticosterone in rats and mice) rise dramatically shortly before birth. This is mimicked clinically in the routine administration of synthetic glucocorticoids to pregnant women threatened by a preterm birth or to preterm infants to improve neonatal survival. Whilst effects on lung are well documented and essential for postnatal survival, those on heart are less well known. In this study, we review recent evidence for a crucial role of glucocorticoids in late gestational heart maturation. Either insufficient or excessive glucocorticoid exposure before birth may alter the normal glucocorticoid-regulated trajectory of heart maturation with potential life-long consequences.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Journal of molecular endocrinology - 52(2014), 2 vom: 07. Apr., Seite R125-35 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rog-Zielinska, Eva A [VerfasserIn] |
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| Links: |
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| Themen: |
Adrenal hormones |
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| Anmerkungen: |
Date Completed 05.11.2014 Date Revised 08.07.2015 published: Electronic-Print Citation Status MEDLINE |
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| doi: |
10.1530/JME-13-0204 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM233295615 |
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| 100 | 1 | |a Rog-Zielinska, Eva A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Glucocorticoids and foetal heart maturation; implications for prematurity and foetal programming |
| 264 | 1 | |c 2014 | |
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| 500 | |a Date Revised 08.07.2015 | ||
| 500 | |a published: Electronic-Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Glucocorticoids are steroid hormones, essential in mammals to prepare for life after birth. Blood levels of glucocorticoids (cortisol in most mammals including humans; corticosterone in rats and mice) rise dramatically shortly before birth. This is mimicked clinically in the routine administration of synthetic glucocorticoids to pregnant women threatened by a preterm birth or to preterm infants to improve neonatal survival. Whilst effects on lung are well documented and essential for postnatal survival, those on heart are less well known. In this study, we review recent evidence for a crucial role of glucocorticoids in late gestational heart maturation. Either insufficient or excessive glucocorticoid exposure before birth may alter the normal glucocorticoid-regulated trajectory of heart maturation with potential life-long consequences | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a adrenal hormones | |
| 650 | 4 | |a cardiovascular | |
| 650 | 4 | |a development | |
| 650 | 4 | |a embryo/foetus | |
| 650 | 4 | |a glucocorticoids | |
| 650 | 7 | |a Glucocorticoids |2 NLM | |
| 650 | 7 | |a Receptors, Glucocorticoid |2 NLM | |
| 700 | 1 | |a Richardson, Rachel V |e verfasserin |4 aut | |
| 700 | 1 | |a Denvir, Martin A |e verfasserin |4 aut | |
| 700 | 1 | |a Chapman, Karen E |e verfasserin |4 aut | |
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