The effect of vaginal sildenafil citrate on uterine blood flow and endometrium in the infertile women
UNLABELLED: Evaluation of endometrial receptivity remains a challenge in clinical practice. Ultrasound evaluation of endometrial thickness and texture and measurement of uterine artery blood flow has been used for endometrial assessment.
AIM: To investigate the role of combination of sildenafil citrate and serophene on endometrial thickness, endometrial volume, endometrial FI and VFI on Angiohistogram, RI and PI to a. uterine on the day of hCG, in prediction of IUI outcome in infertile women.
MATERIALS AND METHODS: Forty two patients were selected randomly who had anovulatory infertility. In Sildenafil citrate plus Serophene group (Group I), patients got 25 mg sildenafil citrate (Silden) vaginally and Serophene 100-150 mg orally, and in Serophene group (Group II), 100-150 mg of Serophene was given orally.
RESULTS: Mean endometrial thickness and endometrial volume was 11.8 +/- 2.6 v/s 10.2 +/- 2.8 and 5.2 +/- 1.4 v/s 3.6 +/- 1.8 respectively in group I and in group II (p < 0.05). There was significant decrease in PI and RI to a. uterina in group I.
CONCLUSIONS: Combination of Sildenafil citrate and Serophene is an effective agent as a first-line of treatment for ovulation induction.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2013 |
|---|---|
| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 Suppl 1 |
|---|---|
| Enthalten in: |
Akusherstvo i ginekologiia - 52 Suppl 1(2013) vom: 20., Seite 26-30 |
| Sprache: |
Bulgarisch |
|---|
| Beteiligte Personen: |
Malinova, M [VerfasserIn] |
|---|
| Themen: |
1HRS458QU2 |
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| Anmerkungen: |
Date Completed 02.01.2014 Date Revised 28.11.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM233247793 |
|---|
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|---|---|---|---|
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| 100 | 1 | |a Malinova, M |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The effect of vaginal sildenafil citrate on uterine blood flow and endometrium in the infertile women |
| 264 | 1 | |c 2013 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 02.01.2014 | ||
| 500 | |a Date Revised 28.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a UNLABELLED: Evaluation of endometrial receptivity remains a challenge in clinical practice. Ultrasound evaluation of endometrial thickness and texture and measurement of uterine artery blood flow has been used for endometrial assessment | ||
| 520 | |a AIM: To investigate the role of combination of sildenafil citrate and serophene on endometrial thickness, endometrial volume, endometrial FI and VFI on Angiohistogram, RI and PI to a. uterine on the day of hCG, in prediction of IUI outcome in infertile women | ||
| 520 | |a MATERIALS AND METHODS: Forty two patients were selected randomly who had anovulatory infertility. In Sildenafil citrate plus Serophene group (Group I), patients got 25 mg sildenafil citrate (Silden) vaginally and Serophene 100-150 mg orally, and in Serophene group (Group II), 100-150 mg of Serophene was given orally | ||
| 520 | |a RESULTS: Mean endometrial thickness and endometrial volume was 11.8 +/- 2.6 v/s 10.2 +/- 2.8 and 5.2 +/- 1.4 v/s 3.6 +/- 1.8 respectively in group I and in group II (p < 0.05). There was significant decrease in PI and RI to a. uterina in group I | ||
| 520 | |a CONCLUSIONS: Combination of Sildenafil citrate and Serophene is an effective agent as a first-line of treatment for ovulation induction | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 7 | |a Fertility Agents, Female |2 NLM | |
| 650 | 7 | |a Piperazines |2 NLM | |
| 650 | 7 | |a Purines |2 NLM | |
| 650 | 7 | |a Sulfones |2 NLM | |
| 650 | 7 | |a Vasodilator Agents |2 NLM | |
| 650 | 7 | |a Clomiphene |2 NLM | |
| 650 | 7 | |a 1HRS458QU2 |2 NLM | |
| 650 | 7 | |a Sildenafil Citrate |2 NLM | |
| 650 | 7 | |a BW9B0ZE037 |2 NLM | |
| 700 | 1 | |a Abouyta, T |e verfasserin |4 aut | |
| 700 | 1 | |a Krasteva, M |e verfasserin |4 aut | |
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