Simplifying antiretroviral therapy to lopinavir/ritonavir monotherapy did not improve quality of life and therapy adherence in pretreated HIV-infected children
We reported quality of life (QOL) and adherence in HIV-infected children after simplifying the antiretroviral regimen by switching to lopinavir/ritonavir monotherapy (mLPV/r). HIV-infected children with HIV-RNA <50 copies/ml while using second-line double boosted protease inhibitors were switched to mLPV/r. Primary caregivers completed PACTG QOL questionnaires at weeks 0, 48, 96, and 144. Adherence by pill count was performed at every visit. Thirty-eight pretreated HIV-infected Thai children were enrolled. The median (IQR) age was 11.5 (10.2-13.2) years and 53% were female. At enrollment, 34 used LPV/r+saquinavir and four used LPV/r+indinavir. The median (IQR) CD4% was 27 (23-30)%. At week 144, QOL scores were similar to baseline for all domains. A transient increase in the symptoms domain score was seen at week 96 (p=0.01), whereas the physical resilience domain score was decreased at weeks 48 and 96 (both p<0.05). Despite the mean number of pills decreasing from 7.9 pills/day before and 3.7 pills/day after mLPV/r (p<0.001), there were no differences over time in adherence rates by pill count and proportion of children with poor adherence (all p>0.05). Our study did not demonstrate improvement of QOL scores and adherence rates by pill count in pretreated HIV-infected children after simplification of the antiretroviral regimen to lopinavir/ritonavir monotherapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
AIDS research and human retroviruses - 30(2014), 3 vom: 17. März, Seite 260-5 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bunupuradah, Torsak [VerfasserIn] |
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| Links: |
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| Themen: |
2494G1JF75 |
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| Anmerkungen: |
Date Completed 17.10.2014 Date Revised 04.03.2014 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1089/AID.2013.0204 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM233054170 |
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| 245 | 1 | 0 | |a Simplifying antiretroviral therapy to lopinavir/ritonavir monotherapy did not improve quality of life and therapy adherence in pretreated HIV-infected children |
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| 520 | |a We reported quality of life (QOL) and adherence in HIV-infected children after simplifying the antiretroviral regimen by switching to lopinavir/ritonavir monotherapy (mLPV/r). HIV-infected children with HIV-RNA <50 copies/ml while using second-line double boosted protease inhibitors were switched to mLPV/r. Primary caregivers completed PACTG QOL questionnaires at weeks 0, 48, 96, and 144. Adherence by pill count was performed at every visit. Thirty-eight pretreated HIV-infected Thai children were enrolled. The median (IQR) age was 11.5 (10.2-13.2) years and 53% were female. At enrollment, 34 used LPV/r+saquinavir and four used LPV/r+indinavir. The median (IQR) CD4% was 27 (23-30)%. At week 144, QOL scores were similar to baseline for all domains. A transient increase in the symptoms domain score was seen at week 96 (p=0.01), whereas the physical resilience domain score was decreased at weeks 48 and 96 (both p<0.05). Despite the mean number of pills decreasing from 7.9 pills/day before and 3.7 pills/day after mLPV/r (p<0.001), there were no differences over time in adherence rates by pill count and proportion of children with poor adherence (all p>0.05). Our study did not demonstrate improvement of QOL scores and adherence rates by pill count in pretreated HIV-infected children after simplification of the antiretroviral regimen to lopinavir/ritonavir monotherapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 650 | 7 | |a Lopinavir |2 NLM | |
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| 650 | 7 | |a Ritonavir |2 NLM | |
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| 700 | 1 | |a Panthong, Apirudee |e verfasserin |4 aut | |
| 700 | 1 | |a Kosalaraksa, Pope |e verfasserin |4 aut | |
| 700 | 1 | |a Wongsabut, Jiratchaya |e verfasserin |4 aut | |
| 700 | 1 | |a Puthanakit, Thanyawee |e verfasserin |4 aut | |
| 700 | 1 | |a Lumbiganon, Pagakrong |e verfasserin |4 aut | |
| 700 | 1 | |a Chuanjaroen, Thongsuai |e verfasserin |4 aut | |
| 700 | 1 | |a Sopharak, Chanasda |e verfasserin |4 aut | |
| 700 | 1 | |a Udompanit, Thanitta |e verfasserin |4 aut | |
| 700 | 1 | |a Prasitsuebsai, Wasana |e verfasserin |4 aut | |
| 700 | 1 | |a Pancharoen, Chitsanu |e verfasserin |4 aut | |
| 700 | 1 | |a Ananworanich, Jintanat |e verfasserin |4 aut | |
| 700 | 0 | |a HIV-NAT 077 Study Team |e verfasserin |4 aut | |
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| 700 | 1 | |a Phasomsap, Chayapa |e investigator |4 oth | |
| 700 | 1 | |a Wongngam, Walaiporn |e investigator |4 oth | |
| 700 | 1 | |a Intasan, Jintana |e investigator |4 oth | |
| 700 | 1 | |a Intakan, Primwichaya |e investigator |4 oth | |
| 700 | 1 | |a Chaiya, Orathai |e investigator |4 oth | |
| 700 | 1 | |a Kerr, Stephen |e investigator |4 oth | |
| 700 | 1 | |a Apornpong, Tanakorn |e investigator |4 oth | |
| 700 | 1 | |a Sriheara, Chulalak |e investigator |4 oth | |
| 700 | 1 | |a Ubolyam, Sasiwimol |e investigator |4 oth | |
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