Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors
HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent one of the most significant classes of drugs for the treatment of AIDS/HIV infection. Over the past two decades several potent arylsulfone-based HIV-1 NNRTIs and related analogs have been developed. This review provides an essential overview of the structure-activity relationships of the arylsulfone-based HIV-1 NNRTIs. Furthermore, structural information useful for the design and development of new sulfur containing NNRTIs with enhanced antiretroviral activity against HIV-1 wild type and clinically relevant drug resistant HIV-1 mutant strains will be discussed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Future medicinal chemistry - 5(2013), 18 vom: 17. Dez., Seite 2141-56 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Famiglini, Valeria [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 23.06.2014 Date Revised 22.11.2013 published: Print Citation Status MEDLINE |
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| doi: |
10.4155/fmc.13.174 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM232930066 |
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| 520 | |a HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent one of the most significant classes of drugs for the treatment of AIDS/HIV infection. Over the past two decades several potent arylsulfone-based HIV-1 NNRTIs and related analogs have been developed. This review provides an essential overview of the structure-activity relationships of the arylsulfone-based HIV-1 NNRTIs. Furthermore, structural information useful for the design and development of new sulfur containing NNRTIs with enhanced antiretroviral activity against HIV-1 wild type and clinically relevant drug resistant HIV-1 mutant strains will be discussed | ||
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| 700 | 1 | |a Brancale, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Pelliccia, Sveva |e verfasserin |4 aut | |
| 700 | 1 | |a La Regina, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Silvestri, Romano |e verfasserin |4 aut | |
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