Role of the QuantiFERON®-TB Gold In-Tube test in the diagnosis of intrathoracic childhood tuberculosis
SETTING: Tertiary care hospitals in India.
OBJECTIVE: To compare the performance of the QuantiFERON®-TB Gold In-Tube test (QFT-GIT) with that of the tuberculin skin test (TST) in the diagnosis of intrathoracic childhood tuberculosis (TB).
METHODS: Children with intrathoracic TB were enrolled in a randomised controlled trial studying micronutrient supplementation in intrathoracic TB. They underwent TST and QFT-GIT before starting daily anti-tuberculosis treatment.
RESULTS: Of 362 children (median age 115.5 months, IQR 73-144, 55% girls) enrolled in the study, microbiological confirmation of TB was obtained in 128 (35%). The TST was positive in 337 (93%, 95%CI 90-95.5) and QFT-GIT in 297 (82%, 95%CI 77.8-85.6). Sensitivity of TST and QFT-GIT in culture-confirmed TB cases was respectively 90.5% (95%CI 84.1-94.5) and 82.6% (95%CI 74.9-88.4). QFT-GIT positivity rate correlated with TST induration (P < 0.001). TST was influenced by the disease spectrum (P = 0.004) and the age of the children (P = 0.002); QFT-GIT remained unaffected by these factors. Bacille Calmette-Guérin immunisation status, weight-for-age Z-scores and microbiological confirmation of Mycobacterium tuberculosis did not influence the performance of either test.
CONCLUSION: In high-burden countries, QFT-GIT is comparable to TST and offers no added advantage in the diagnosis of childhood intrathoracic TB.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 17(2013), 11 vom: 05. Nov., Seite 1383-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lodha, R [VerfasserIn] |
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| Links: |
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| Themen: |
Antitubercular Agents |
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| Anmerkungen: |
Date Completed 30.05.2014 Date Revised 15.10.2013 published: Print Citation Status MEDLINE |
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| doi: |
10.5588/ijtld.13.0348 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM231697430 |
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| 041 | |a eng | ||
| 100 | 1 | |a Lodha, R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Role of the QuantiFERON®-TB Gold In-Tube test in the diagnosis of intrathoracic childhood tuberculosis |
| 264 | 1 | |c 2013 | |
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| 500 | |a Date Completed 30.05.2014 | ||
| 500 | |a Date Revised 15.10.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a SETTING: Tertiary care hospitals in India | ||
| 520 | |a OBJECTIVE: To compare the performance of the QuantiFERON®-TB Gold In-Tube test (QFT-GIT) with that of the tuberculin skin test (TST) in the diagnosis of intrathoracic childhood tuberculosis (TB) | ||
| 520 | |a METHODS: Children with intrathoracic TB were enrolled in a randomised controlled trial studying micronutrient supplementation in intrathoracic TB. They underwent TST and QFT-GIT before starting daily anti-tuberculosis treatment | ||
| 520 | |a RESULTS: Of 362 children (median age 115.5 months, IQR 73-144, 55% girls) enrolled in the study, microbiological confirmation of TB was obtained in 128 (35%). The TST was positive in 337 (93%, 95%CI 90-95.5) and QFT-GIT in 297 (82%, 95%CI 77.8-85.6). Sensitivity of TST and QFT-GIT in culture-confirmed TB cases was respectively 90.5% (95%CI 84.1-94.5) and 82.6% (95%CI 74.9-88.4). QFT-GIT positivity rate correlated with TST induration (P < 0.001). TST was influenced by the disease spectrum (P = 0.004) and the age of the children (P = 0.002); QFT-GIT remained unaffected by these factors. Bacille Calmette-Guérin immunisation status, weight-for-age Z-scores and microbiological confirmation of Mycobacterium tuberculosis did not influence the performance of either test | ||
| 520 | |a CONCLUSION: In high-burden countries, QFT-GIT is comparable to TST and offers no added advantage in the diagnosis of childhood intrathoracic TB | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antitubercular Agents |2 NLM | |
| 700 | 1 | |a Mukherjee, A |e verfasserin |4 aut | |
| 700 | 1 | |a Saini, D |e verfasserin |4 aut | |
| 700 | 1 | |a Saini, S |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, V |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, S |e verfasserin |4 aut | |
| 700 | 1 | |a Grewal, H M S |e verfasserin |4 aut | |
| 700 | 1 | |a Kabra, S K |e verfasserin |4 aut | |
| 700 | 0 | |a Delhi TB Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Arya, T |e investigator |4 oth | |
| 700 | 1 | |a Bhatnagar, S |e investigator |4 oth | |
| 700 | 1 | |a Chandra, J |e investigator |4 oth | |
| 700 | 1 | |a Dutta, A K |e investigator |4 oth | |
| 700 | 1 | |a Doherty, T M |e investigator |4 oth | |
| 700 | 1 | |a Friis, H |e investigator |4 oth | |
| 700 | 1 | |a Grewal, H M S |e investigator |4 oth | |
| 700 | 1 | |a Hesseling, A C |e investigator |4 oth | |
| 700 | 1 | |a Kabra, S K |e investigator |4 oth | |
| 700 | 1 | |a Lodha, R |e investigator |4 oth | |
| 700 | 1 | |a Marais, B |e investigator |4 oth | |
| 700 | 1 | |a Mukherjee, A |e investigator |4 oth | |
| 700 | 1 | |a Parashar, D |e investigator |4 oth | |
| 700 | 1 | |a Prajapati, S |e investigator |4 oth | |
| 700 | 1 | |a Purohit, K |e investigator |4 oth | |
| 700 | 1 | |a Saini, D |e investigator |4 oth | |
| 700 | 1 | |a Saini, S |e investigator |4 oth | |
| 700 | 1 | |a Singh, R R |e investigator |4 oth | |
| 700 | 1 | |a Singh, S |e investigator |4 oth | |
| 700 | 1 | |a Singh, V |e investigator |4 oth | |
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