Cellular and intracellular transport of vitamin C. The physiologic aspects
Vitamin C requirement is satisfied by natural sources and vitamin C supplements in the ordinary human diet. The two major forms of vitamin C in the diet are L-ascorbic acid and L-dehydroascorbic acid. Both ascorbate and dehydroascorbate are absorbed along the entire length of the human intestine. The reduced form, L-ascorbic acid is imported by an active mechanism, requiring two sodium-dependent vitamin C transporters (SVCT1 and SVCT2). The transport of the oxidized form, dehydroascorbate is mediated by glucose transporters GLUT1, GLUT3 and possibly GLUT4. Initial rate of uptake of both ascorbate and dehydroascorbate is saturable with increasing external substrate concentration. Vitamin C plasma concentrations are tightly controlled when the vitamin is taken orally. It has two simple reasons, on the one hand, the capacity of the transporters is limited, on the other hand the two Na+-dependent transporters can be down-regulated by an elevated level of ascorbate.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:154 |
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| Enthalten in: |
Orvosi hetilap - 154(2013), 42 vom: 20. Okt., Seite 1651-6 |
| Sprache: |
Ungarisch |
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| Weiterer Titel: |
A C-vitamin celluláris, intracelluláris transzportja. Fiziológiai vonatkozások |
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| Beteiligte Personen: |
Szarka, András [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.03.2014 Date Revised 14.10.2013 published: Print Citation Status MEDLINE |
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| doi: |
10.1556/OH.2013.29712 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Cellular and intracellular transport of vitamin C. The physiologic aspects |
| 246 | 3 | 3 | |a A C-vitamin celluláris, intracelluláris transzportja. Fiziológiai vonatkozások |
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| 500 | |a Date Revised 14.10.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Vitamin C requirement is satisfied by natural sources and vitamin C supplements in the ordinary human diet. The two major forms of vitamin C in the diet are L-ascorbic acid and L-dehydroascorbic acid. Both ascorbate and dehydroascorbate are absorbed along the entire length of the human intestine. The reduced form, L-ascorbic acid is imported by an active mechanism, requiring two sodium-dependent vitamin C transporters (SVCT1 and SVCT2). The transport of the oxidized form, dehydroascorbate is mediated by glucose transporters GLUT1, GLUT3 and possibly GLUT4. Initial rate of uptake of both ascorbate and dehydroascorbate is saturable with increasing external substrate concentration. Vitamin C plasma concentrations are tightly controlled when the vitamin is taken orally. It has two simple reasons, on the one hand, the capacity of the transporters is limited, on the other hand the two Na+-dependent transporters can be down-regulated by an elevated level of ascorbate | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a C-vitamin | |
| 650 | 4 | |a napi ajánlott bevitel | |
| 650 | 4 | |a recommended daily allowance | |
| 650 | 4 | |a transport | |
| 650 | 4 | |a transzport | |
| 650 | 4 | |a vitamin C | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Glucose Transporter Type 1 |2 NLM | |
| 650 | 7 | |a Glucose Transporter Type 3 |2 NLM | |
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| 650 | 7 | |a SLC2A3 protein, human |2 NLM | |
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| 650 | 7 | |a Sodium-Coupled Vitamin C Transporters |2 NLM | |
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| 650 | 7 | |a Dehydroascorbic Acid |2 NLM | |
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| 700 | 1 | |a Lőrincz, Tamás |e verfasserin |4 aut | |
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