p16 status, pathologic and clinical characteristics, biomolecular signature, and long-term outcomes in head and neck squamous cell carcinomas of unknown primary
© 2014 Wiley Periodicals, Inc..
BACKGROUND: The purpose of this study was to report associations between p16 status, clinicopathologic characteristics, and outcomes for head and neck squamous cell carcinoma of unknown primary (CUP).
METHODS: Specimens of squamous cell CUP were reanalyzed. Human papillomavirus (HPV) status was determined by p16 stain. A tissue microarray (TMA) was constructed to evaluate biomarkers potentially prognostic in head and neck squamous cell carcinoma (HNSCC).
RESULTS: A majority of the population (n = 26; 74%) was p16 positive (+). Prognostic factors benefiting survival were p16+ status (p < .0001), absence of macroscopic extracapsular extension (ECE; p = .004), younger age (p = .01), and higher grade (p = 0.007). The prognostic implication of worse overall survival (OS) with macroscopic ECE (p = .009) remained significant when limited to patients who were p16+ (p = .002). Exploratory TMA between unknown primary and controls suggested a biomolecular difference between squamous cell CUP and known-primary cancer.
CONCLUSION: The majority of patients with squamous cell CUP were p16+, indicative of HPV association. P16 staining and ECE seem to be the most prognostic features in squamous cell CUP.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
Head & neck - 36(2014), 12 vom: 11. Dez., Seite 1677-84 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Keller, Lanea M [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.07.2015 Date Revised 08.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/hed.23514 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM231599579 |
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| 100 | 1 | |a Keller, Lanea M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a p16 status, pathologic and clinical characteristics, biomolecular signature, and long-term outcomes in head and neck squamous cell carcinomas of unknown primary |
| 264 | 1 | |c 2014 | |
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| 500 | |a Date Completed 14.07.2015 | ||
| 500 | |a Date Revised 08.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2014 Wiley Periodicals, Inc. | ||
| 520 | |a BACKGROUND: The purpose of this study was to report associations between p16 status, clinicopathologic characteristics, and outcomes for head and neck squamous cell carcinoma of unknown primary (CUP) | ||
| 520 | |a METHODS: Specimens of squamous cell CUP were reanalyzed. Human papillomavirus (HPV) status was determined by p16 stain. A tissue microarray (TMA) was constructed to evaluate biomarkers potentially prognostic in head and neck squamous cell carcinoma (HNSCC) | ||
| 520 | |a RESULTS: A majority of the population (n = 26; 74%) was p16 positive (+). Prognostic factors benefiting survival were p16+ status (p < .0001), absence of macroscopic extracapsular extension (ECE; p = .004), younger age (p = .01), and higher grade (p = 0.007). The prognostic implication of worse overall survival (OS) with macroscopic ECE (p = .009) remained significant when limited to patients who were p16+ (p = .002). Exploratory TMA between unknown primary and controls suggested a biomolecular difference between squamous cell CUP and known-primary cancer | ||
| 520 | |a CONCLUSION: The majority of patients with squamous cell CUP were p16+, indicative of HPV association. P16 staining and ECE seem to be the most prognostic features in squamous cell CUP | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a concurrent chemotherapy | |
| 650 | 4 | |a extracapsular extension (ECE) | |
| 650 | 4 | |a human papillomavirus (HPV) | |
| 650 | 4 | |a tissue microarray | |
| 650 | 4 | |a unknown primary | |
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| 650 | 7 | |a Neoplasm Proteins |2 NLM | |
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| 700 | 1 | |a Holdbrook, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Ruth, Karen |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Donghua |e verfasserin |4 aut | |
| 700 | 1 | |a Dubyk, Cara |e verfasserin |4 aut | |
| 700 | 1 | |a Flieder, Douglas |e verfasserin |4 aut | |
| 700 | 1 | |a Lango, Miriam N |e verfasserin |4 aut | |
| 700 | 1 | |a Mehra, Ranee |e verfasserin |4 aut | |
| 700 | 1 | |a Burtness, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Ridge, John A |e verfasserin |4 aut | |
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