The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved..
We investigated truncated glioma-associated oncogene homolog 1 (TGLI1) that behaves as gain-of-function GLI1 and promotes tumor cell migration and invasion. Herein, we report that TGLI1 had a higher propensity than GLI1 to enhance glioblastoma angiogenesis and growth, both in vivo and in vitro. TGLI1 has gained the ability to enhance expression of pro-angiogenic heparanase. In patient glioblastomas, TGLI1 levels are correlated with heparanase expression. Together, we report that TGLI1 is a novel mediator of glioblastoma angiogenesis and that heparanase is a novel transcriptional target of TGLI1, shedding new light on the molecular pathways that support tumor angiogenesis and aggressive growth.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:343 |
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| Enthalten in: |
Cancer letters - 343(2014), 1 vom: 01. Feb., Seite 51-61 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhu, Hu [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.02.2014 Date Revised 21.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.canlet.2013.09.014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM230956114 |
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| 245 | 1 | 4 | |a The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth |
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| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. | ||
| 520 | |a We investigated truncated glioma-associated oncogene homolog 1 (TGLI1) that behaves as gain-of-function GLI1 and promotes tumor cell migration and invasion. Herein, we report that TGLI1 had a higher propensity than GLI1 to enhance glioblastoma angiogenesis and growth, both in vivo and in vitro. TGLI1 has gained the ability to enhance expression of pro-angiogenic heparanase. In patient glioblastomas, TGLI1 levels are correlated with heparanase expression. Together, we report that TGLI1 is a novel mediator of glioblastoma angiogenesis and that heparanase is a novel transcriptional target of TGLI1, shedding new light on the molecular pathways that support tumor angiogenesis and aggressive growth | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Angiogenesis | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a GLI1 | |
| 650 | 4 | |a Hedgehog pathway | |
| 650 | 4 | |a Transcriptional regulation | |
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| 700 | 1 | |a Carpenter, Richard L |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Woody |e verfasserin |4 aut | |
| 700 | 1 | |a Lo, Hui-Wen |e verfasserin |4 aut | |
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