Changes in serum levels of selenium, zinc and copper in patients on a ketogenic diet using Ketonformula
OBJECTIVE: Ketogenic diets tend to cause trace mineral deficiencies. Ketonformula is a foumula for a ketogenic diet developed by Meiji Co Ltd in Japan. No reports are available on the trace mineral deficiencies associated with a use of Ketonformula.
METHODS: We monitored the serum levels of selenium, zinc and copper as well as the amount of the daily intake of these minerals before and at 6 months after the initiation of the ketogenic diet with Ketonformula in six patients with intractable epilepsy associated with severe motor and intellectual disabilities.
RESULT: The median serum selenium concentration decreased from 7.0 (range, 6.5-12.3) microg/dl to 6.2 (5.4-10.9) microg/dl as a result of the 6-month-treatment with Ketonformula (p < 0.05, Wilcoxon signed-rank test). The median daily selenium intake decreased from 17.8 (15.0-27.0) microg/day at the baseline to 5.5 (5.0-22.0) microg/day after 6 months on the diet (p < 0.05). The median serum zinc concentration increased slightly (from 66.0 (46.0-84.0) microg/dl to 68.0 (46.0-71.0) microg/dl), but the difference was not significant. The median daily zinc intake, however, significantly decreased from 4.2 (3.7-6.0) mg/day to 2.2 (2.0-3.0) mg/day (p < 0.05). The median serum copper concentration also showed no significant decrease (from 134.5 (119.0-168.0) microg/dl to 126.0 (86.0-183.0) microg/dl). The median daily copper intakes, however, decreased significantly from 0.80 (0.35-1.30) mg/day to 0.30 (0.26-0.40) mg/day (p < 0.05).
CONCLUSIONS: The decline of the serum selenium concentrations and daily enteral intakes of selenium, zinc, and copper after 6 months on Ketonformula suggested that patients on this ketogenic formula needs close monitoring as well as supplementation of these trace minerals.
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2013 |
---|---|
Erschienen: |
2013 |
Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
---|---|
Enthalten in: |
No to hattatsu = Brain and development - 45(2013), 4 vom: 16. Juli, Seite 288-93 |
Sprache: |
Japanisch |
---|
Beteiligte Personen: |
Hayashi, Anri [VerfasserIn] |
---|
Themen: |
789U1901C5 |
---|
Anmerkungen: |
Date Completed 13.11.2013 Date Revised 22.02.2018 published: Print Citation Status MEDLINE |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
NLM230087566 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM230087566 | ||
003 | DE-627 | ||
005 | 20231224083606.0 | ||
007 | tu | ||
008 | 231224s2013 xx ||||| 00| ||jpn c | ||
028 | 5 | 2 | |a pubmed24n0767.xml |
035 | |a (DE-627)NLM230087566 | ||
035 | |a (NLM)23951940 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a jpn | ||
100 | 1 | |a Hayashi, Anri |e verfasserin |4 aut | |
245 | 1 | 0 | |a Changes in serum levels of selenium, zinc and copper in patients on a ketogenic diet using Ketonformula |
264 | 1 | |c 2013 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a Date Completed 13.11.2013 | ||
500 | |a Date Revised 22.02.2018 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a OBJECTIVE: Ketogenic diets tend to cause trace mineral deficiencies. Ketonformula is a foumula for a ketogenic diet developed by Meiji Co Ltd in Japan. No reports are available on the trace mineral deficiencies associated with a use of Ketonformula | ||
520 | |a METHODS: We monitored the serum levels of selenium, zinc and copper as well as the amount of the daily intake of these minerals before and at 6 months after the initiation of the ketogenic diet with Ketonformula in six patients with intractable epilepsy associated with severe motor and intellectual disabilities | ||
520 | |a RESULT: The median serum selenium concentration decreased from 7.0 (range, 6.5-12.3) microg/dl to 6.2 (5.4-10.9) microg/dl as a result of the 6-month-treatment with Ketonformula (p < 0.05, Wilcoxon signed-rank test). The median daily selenium intake decreased from 17.8 (15.0-27.0) microg/day at the baseline to 5.5 (5.0-22.0) microg/day after 6 months on the diet (p < 0.05). The median serum zinc concentration increased slightly (from 66.0 (46.0-84.0) microg/dl to 68.0 (46.0-71.0) microg/dl), but the difference was not significant. The median daily zinc intake, however, significantly decreased from 4.2 (3.7-6.0) mg/day to 2.2 (2.0-3.0) mg/day (p < 0.05). The median serum copper concentration also showed no significant decrease (from 134.5 (119.0-168.0) microg/dl to 126.0 (86.0-183.0) microg/dl). The median daily copper intakes, however, decreased significantly from 0.80 (0.35-1.30) mg/day to 0.30 (0.26-0.40) mg/day (p < 0.05) | ||
520 | |a CONCLUSIONS: The decline of the serum selenium concentrations and daily enteral intakes of selenium, zinc, and copper after 6 months on Ketonformula suggested that patients on this ketogenic formula needs close monitoring as well as supplementation of these trace minerals | ||
650 | 4 | |a Journal Article | |
650 | 7 | |a Copper |2 NLM | |
650 | 7 | |a 789U1901C5 |2 NLM | |
650 | 7 | |a Selenium |2 NLM | |
650 | 7 | |a H6241UJ22B |2 NLM | |
650 | 7 | |a Zinc |2 NLM | |
650 | 7 | |a J41CSQ7QDS |2 NLM | |
700 | 1 | |a Kumada, Tomohiro |e verfasserin |4 aut | |
700 | 1 | |a Nozaki, Fumihito |e verfasserin |4 aut | |
700 | 1 | |a Hiejima, Ikuko |e verfasserin |4 aut | |
700 | 1 | |a Miyajima, Tomoko |e verfasserin |4 aut | |
700 | 1 | |a Fujii, Tatsuya |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t No to hattatsu = Brain and development |d 1983 |g 45(2013), 4 vom: 16. Juli, Seite 288-93 |w (DE-627)NLM012910074 |x 0029-0831 |7 nnns |
773 | 1 | 8 | |g volume:45 |g year:2013 |g number:4 |g day:16 |g month:07 |g pages:288-93 |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 45 |j 2013 |e 4 |b 16 |c 07 |h 288-93 |