Identification and characterization of two novel viruses in ocular infections in reindeer
A thorough understanding of virus diversity in wildlife provides epidemiological baseline information about pathogens. In this study, eye swab samples were obtained from semi-domesticated reindeer (Rangifertarandus tarandus) in Norway during an outbreak of infectious eye disease, possibly a very early stage of infectious keratoconjunctivitis (IKC). Large scale molecular virus screening, based on host nucleic acid depletion, sequence-independent amplification and next-generation sequencing of partially purified viral nucleic acid, revealed the presence of a new papillomavirus in 2 out of 8 eye swab samples and a new betaherpesvirus in 3 out of 8 eye swab samples collected from animals with clinical signs and not in similar samples in 9 animals without clinical signs. Whether either virus was responsible for causing the clinical signs or in any respect was associated to the disease condition remains to be determined.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
PloS one - 8(2013), 7 vom: 15., Seite e69711 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Smits, Saskia L [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 19.02.2014 Date Revised 21.10.2021 published: Electronic-Print Citation Status MEDLINE |
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| doi: |
10.1371/journal.pone.0069711 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM229354920 |
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| 245 | 1 | 0 | |a Identification and characterization of two novel viruses in ocular infections in reindeer |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A thorough understanding of virus diversity in wildlife provides epidemiological baseline information about pathogens. In this study, eye swab samples were obtained from semi-domesticated reindeer (Rangifertarandus tarandus) in Norway during an outbreak of infectious eye disease, possibly a very early stage of infectious keratoconjunctivitis (IKC). Large scale molecular virus screening, based on host nucleic acid depletion, sequence-independent amplification and next-generation sequencing of partially purified viral nucleic acid, revealed the presence of a new papillomavirus in 2 out of 8 eye swab samples and a new betaherpesvirus in 3 out of 8 eye swab samples collected from animals with clinical signs and not in similar samples in 9 animals without clinical signs. Whether either virus was responsible for causing the clinical signs or in any respect was associated to the disease condition remains to be determined | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Schapendonk, Claudia M E |e verfasserin |4 aut | |
| 700 | 1 | |a van Leeuwen, Marije |e verfasserin |4 aut | |
| 700 | 1 | |a Kuiken, Thijs |e verfasserin |4 aut | |
| 700 | 1 | |a Bodewes, Rogier |e verfasserin |4 aut | |
| 700 | 1 | |a Stalin Raj, V |e verfasserin |4 aut | |
| 700 | 1 | |a Haagmans, Bart L |e verfasserin |4 aut | |
| 700 | 1 | |a das Neves, Carlos G |e verfasserin |4 aut | |
| 700 | 1 | |a Tryland, Morten |e verfasserin |4 aut | |
| 700 | 1 | |a Osterhaus, Albert D M E |e verfasserin |4 aut | |
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