Circulating tumor cells predict progression-free and overall survival in Chinese patients with metastatic breast cancer, HER2-positive or triple-negative (CBCSG004) : a multicenter, double-blind, prospective trial
BACKGROUND: The aim of this multicenter, double-blind, prospective study was to evaluate the potential utility of circulating tumor cell (CTC) measurements in predicting responses to anticancer therapies, including response to human epidermal growth factor receptor-2 (HER-2)-targeted agents, progression-free survival (PFS), and overall survival (OS) in Chinese women with metastatic breast cancer (MBC).
PATIENTS AND METHODS: Three hundred MBC patients planned to complete three CTC blood draws and two imaging studies.
RESULTS: A total of 294 of the 300 MBC patients enrolled from six leading Chinese cancer centers were assessable. In multivariate Cox regression analyses, the baseline CTC number remained an independent prognostic factor for PFS [hazard ratio (HR) = 1.93; 95% confidence interval (CI) = 1.39-2.69; P < 0.001) and OS (HR = 3.76; 95% CI = 2.35-6.01; P < 0.001). Similar results were observed for CTC counts at the first follow-up visit for both PFS (P = 0.049) and OS (P < 0.001).
CONCLUSIONS: Enumeration of CTCs in Chinese MBC patients provides substantial prognostic information and is an independent factor associated with PFS and OS. Moreover, we demonstrated the prognostic value in the various disease subtypes, including HER-2-positive disease irrespective of therapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Annals of oncology : official journal of the European Society for Medical Oncology - 24(2013), 11 vom: 19. Nov., Seite 2766-72 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jiang, Z F [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.06.2014 Date Revised 18.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1093/annonc/mdt246 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Jiang, Z F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Circulating tumor cells predict progression-free and overall survival in Chinese patients with metastatic breast cancer, HER2-positive or triple-negative (CBCSG004) |b a multicenter, double-blind, prospective trial |
| 264 | 1 | |c 2013 | |
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| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 02.06.2014 | ||
| 500 | |a Date Revised 18.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The aim of this multicenter, double-blind, prospective study was to evaluate the potential utility of circulating tumor cell (CTC) measurements in predicting responses to anticancer therapies, including response to human epidermal growth factor receptor-2 (HER-2)-targeted agents, progression-free survival (PFS), and overall survival (OS) in Chinese women with metastatic breast cancer (MBC) | ||
| 520 | |a PATIENTS AND METHODS: Three hundred MBC patients planned to complete three CTC blood draws and two imaging studies | ||
| 520 | |a RESULTS: A total of 294 of the 300 MBC patients enrolled from six leading Chinese cancer centers were assessable. In multivariate Cox regression analyses, the baseline CTC number remained an independent prognostic factor for PFS [hazard ratio (HR) = 1.93; 95% confidence interval (CI) = 1.39-2.69; P < 0.001) and OS (HR = 3.76; 95% CI = 2.35-6.01; P < 0.001). Similar results were observed for CTC counts at the first follow-up visit for both PFS (P = 0.049) and OS (P < 0.001) | ||
| 520 | |a CONCLUSIONS: Enumeration of CTCs in Chinese MBC patients provides substantial prognostic information and is an independent factor associated with PFS and OS. Moreover, we demonstrated the prognostic value in the various disease subtypes, including HER-2-positive disease irrespective of therapy | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a circulating tumor cells | |
| 650 | 4 | |a metastatic breast cancer | |
| 650 | 4 | |a overall survival | |
| 650 | 4 | |a progression-free survival | |
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| 700 | 1 | |a Cristofanilli, M |e verfasserin |4 aut | |
| 700 | 1 | |a Shao, Z M |e verfasserin |4 aut | |
| 700 | 1 | |a Tong, Z S |e verfasserin |4 aut | |
| 700 | 1 | |a Song, E W |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, X J |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, N |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, X C |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Y |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Y |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, L |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, M |e verfasserin |4 aut | |
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