Causes of death and risk factors for mortality among HIV-infected patients receiving antiretroviral therapy in Korea
A retrospective study was conducted to determine the mortality, causes and risk factors for death among HIV-infected patients receiving antiretroviral therapy (ART) in Korea. The outcomes were determined by time periods, during the first year of ART and during 1-5 yr after ART initiation, respectively. Patients lost to follow-up were traced to ascertain survival status. Among 327 patients initiating ART during 1998-2006, 68 patients (20.8%) died during 5-yr follow-up periods. Mortality rate per 100 person-years was 8.69 (95% confidence interval, 5.68-12.73) during the first year of ART, which was higher than 4.13 (95% confidence interval, 2.98-5.59) during 1-5 yr after ART. Tuberculosis was the most common cause of death in both periods (30.8% within the first year of ART and 16.7% during 1-5 yr after ART). During the first year of ART, clinical category B and C at ART initiation, and underlying malignancy were significant risk factors for mortality. Between 1 and 5 yr after ART initiation, CD4 cell count ≤ 50 cells/µL at ART initiation, hepatitis B virus co-infection, and visit constancy ≤ 50% were significant risk factors for death. This suggests that different strategies to reduce mortality according to the time period after ART initiation are needed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Journal of Korean medical science - 28(2013), 7 vom: 01. Juli, Seite 990-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Sun Hee [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Retroviral Agents |
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| Anmerkungen: |
Date Completed 21.03.2014 Date Revised 11.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.3346/jkms.2013.28.7.990 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM229160921 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A retrospective study was conducted to determine the mortality, causes and risk factors for death among HIV-infected patients receiving antiretroviral therapy (ART) in Korea. The outcomes were determined by time periods, during the first year of ART and during 1-5 yr after ART initiation, respectively. Patients lost to follow-up were traced to ascertain survival status. Among 327 patients initiating ART during 1998-2006, 68 patients (20.8%) died during 5-yr follow-up periods. Mortality rate per 100 person-years was 8.69 (95% confidence interval, 5.68-12.73) during the first year of ART, which was higher than 4.13 (95% confidence interval, 2.98-5.59) during 1-5 yr after ART. Tuberculosis was the most common cause of death in both periods (30.8% within the first year of ART and 16.7% during 1-5 yr after ART). During the first year of ART, clinical category B and C at ART initiation, and underlying malignancy were significant risk factors for mortality. Between 1 and 5 yr after ART initiation, CD4 cell count ≤ 50 cells/µL at ART initiation, hepatitis B virus co-infection, and visit constancy ≤ 50% were significant risk factors for death. This suggests that different strategies to reduce mortality according to the time period after ART initiation are needed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Antiretroviral Therapy | |
| 650 | 4 | |a Cause of Death | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a Loss to Follow-up | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Retention in Care | |
| 650 | 4 | |a Risk Factors | |
| 650 | 4 | |a Visit Constancy | |
| 650 | 7 | |a Anti-Retroviral Agents |2 NLM | |
| 700 | 1 | |a Kim, Kye-Hyung |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Seung Geun |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Heerim |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Dong Hwan |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Joo Seop |e verfasserin |4 aut | |
| 700 | 1 | |a Kwak, Ihm Soo |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Goon Jae |e verfasserin |4 aut | |
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