An expedient protecting-group-free total synthesis of (±)-dievodiamine
The first total synthesis of the Evodia rutaecarpa derived natural product dievodiamine is described. The convergent synthesis was performed without protecting groups, delivering a route that is short and high yielding and uses limited chromatography. Key steps include organometallic addition into a DHED adduct and the Stille coupling of two advanced intermediates to complete the synthesis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Organic letters - 15(2013), 13 vom: 05. Juli, Seite 3302-5 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Unsworth, William P [VerfasserIn] |
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| Links: |
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| Themen: |
Biological Factors |
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| Anmerkungen: |
Date Completed 08.01.2014 Date Revised 25.11.2016 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/ol4013469 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM22851245X |
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| 100 | 1 | |a Unsworth, William P |e verfasserin |4 aut | |
| 245 | 1 | 3 | |a An expedient protecting-group-free total synthesis of (±)-dievodiamine |
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| 500 | |a Date Completed 08.01.2014 | ||
| 500 | |a Date Revised 25.11.2016 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The first total synthesis of the Evodia rutaecarpa derived natural product dievodiamine is described. The convergent synthesis was performed without protecting groups, delivering a route that is short and high yielding and uses limited chromatography. Key steps include organometallic addition into a DHED adduct and the Stille coupling of two advanced intermediates to complete the synthesis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Biological Factors |2 NLM | |
| 650 | 7 | |a Heterocyclic Compounds, 4 or More Rings |2 NLM | |
| 650 | 7 | |a Indoles |2 NLM | |
| 650 | 7 | |a Organometallic Compounds |2 NLM | |
| 650 | 7 | |a dehydroevodiamine hydrochloride |2 NLM | |
| 650 | 7 | |a dievodiamine |2 NLM | |
| 700 | 1 | |a Kitsiou, Christiana |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, Richard J K |e verfasserin |4 aut | |
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