Anti-inflammatory effect of the serratiopeptidase--rationale or fashionable : a study in rat paw oedema model induced by the carrageenan
INTRODUCTION: Many drugs, including serratiopeptidases, are marketed without proven efficacy in clinical trials. It is protein in nature and claimed to be effective orally.
METHODS: 24 albino wistar rats, 6 each in following groups were assigned--(1) Control group (distilled water, orally) (2) Diclofenac (6.75 mg/kg, IP) (3) serratiopeptidase (5.4 mg/kg, orally) (4) Combination of serratiopeptidase (5.4 mg/kg, orally) and diclofenac (2.25 mg/kg, IP). Inflammatory agent, carrageenan (0.1 ml of 1% w/v) was injected subcutaneously in the ether anesthetized rat hind paw, half an hour after the administration of drug. Rat paw volume up to lateral malleolar process was recorded with plethysmometer at various time periods.
RESULTS: Percentage formation and inhibition of oedema in serratiopeptidase or combination groups were not significantly different than control group. Both were significantly less for diclofenac group.
CONCLUSION: Serratiopeptidase was not effective in this animal model of oedema/inflammation.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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| Enthalten in: |
Indian journal of physiology and pharmacology - 56(2012), 4 vom: 28. Okt., Seite 367-74 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Joshi, Kalpesh K [VerfasserIn] |
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| Themen: |
144O8QL0L1 |
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| Anmerkungen: |
Date Completed 21.08.2013 Date Revised 16.03.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM228475112 |
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| 100 | 1 | |a Joshi, Kalpesh K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Anti-inflammatory effect of the serratiopeptidase--rationale or fashionable |b a study in rat paw oedema model induced by the carrageenan |
| 264 | 1 | |c 2012 | |
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| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 21.08.2013 | ||
| 500 | |a Date Revised 16.03.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Many drugs, including serratiopeptidases, are marketed without proven efficacy in clinical trials. It is protein in nature and claimed to be effective orally | ||
| 520 | |a METHODS: 24 albino wistar rats, 6 each in following groups were assigned--(1) Control group (distilled water, orally) (2) Diclofenac (6.75 mg/kg, IP) (3) serratiopeptidase (5.4 mg/kg, orally) (4) Combination of serratiopeptidase (5.4 mg/kg, orally) and diclofenac (2.25 mg/kg, IP). Inflammatory agent, carrageenan (0.1 ml of 1% w/v) was injected subcutaneously in the ether anesthetized rat hind paw, half an hour after the administration of drug. Rat paw volume up to lateral malleolar process was recorded with plethysmometer at various time periods | ||
| 520 | |a RESULTS: Percentage formation and inhibition of oedema in serratiopeptidase or combination groups were not significantly different than control group. Both were significantly less for diclofenac group | ||
| 520 | |a CONCLUSION: Serratiopeptidase was not effective in this animal model of oedema/inflammation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
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| 650 | 7 | |a serratiopeptidase |2 NLM | |
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| 700 | 1 | |a Nerurkar, Rajan P |e verfasserin |4 aut | |
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