Aerosol transmission is an important mode of influenza A virus spread
Influenza A viruses are believed to spread between humans through contact, large respiratory droplets and small particle droplet nuclei (aerosols), but the relative importance of each of these modes of transmission is unclear. Volunteer studies suggest that infections via aerosol transmission may have a higher risk of febrile illness. Here we apply a mathematical model to data from randomized controlled trials of hand hygiene and surgical face masks in Hong Kong and Bangkok households. In these particular environments, inferences on the relative importance of modes of transmission are facilitated by information on the timing of secondary infections and apparent differences in clinical presentation of secondary infections resulting from aerosol transmission. We find that aerosol transmission accounts for approximately half of all transmission events. This implies that measures to reduce transmission by contact or large droplets may not be sufficient to control influenza A virus transmission in households.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:4 |
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| Enthalten in: |
Nature communications - 4(2013) vom: 04., Seite 1935 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cowling, Benjamin J [VerfasserIn] |
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| Links: |
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| Themen: |
Aerosols |
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| Anmerkungen: |
Date Completed 30.12.2013 Date Revised 21.10.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1038/ncomms2922 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM228067839 |
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| 520 | |a Influenza A viruses are believed to spread between humans through contact, large respiratory droplets and small particle droplet nuclei (aerosols), but the relative importance of each of these modes of transmission is unclear. Volunteer studies suggest that infections via aerosol transmission may have a higher risk of febrile illness. Here we apply a mathematical model to data from randomized controlled trials of hand hygiene and surgical face masks in Hong Kong and Bangkok households. In these particular environments, inferences on the relative importance of modes of transmission are facilitated by information on the timing of secondary infections and apparent differences in clinical presentation of secondary infections resulting from aerosol transmission. We find that aerosol transmission accounts for approximately half of all transmission events. This implies that measures to reduce transmission by contact or large droplets may not be sufficient to control influenza A virus transmission in households | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 700 | 1 | |a Ip, Dennis K M |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Vicky J |e verfasserin |4 aut | |
| 700 | 1 | |a Suntarattiwong, Piyarat |e verfasserin |4 aut | |
| 700 | 1 | |a Olsen, Sonja J |e verfasserin |4 aut | |
| 700 | 1 | |a Levy, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Uyeki, Timothy M |e verfasserin |4 aut | |
| 700 | 1 | |a Leung, Gabriel M |e verfasserin |4 aut | |
| 700 | 1 | |a Malik Peiris, J S |e verfasserin |4 aut | |
| 700 | 1 | |a Chotpitayasunondh, Tawee |e verfasserin |4 aut | |
| 700 | 1 | |a Nishiura, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Mark Simmerman, James |e verfasserin |4 aut | |
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