Change in the blood cytokine spectrum in patients with pulmonary sarcoidosis
AIM: To assess cytokine spectrum changes in different types of pulmonary sarcoidosis (PS).
SUBJECTS AND METHODS: Twenty-seven PS patients without signs of pulmonary fibrosis and 14 patients with sarcoidosis complicated by pulmonary fibrosis were examined. Baseline serum Th1 and Th2 cytokine concentrations were studied. A control group comprised 30 healthy donors.
RESULTS: A higher interleukin (IL)-4/IL-2 ratio was found in the peripheral blood of the patients with pulmonary fibrosis-complicated sarcoidosis than in the other patients (326.4 +/- 122.6 and 88.2 +/- 28.6%, respectively; p = 0.002). The sarcoidosis patients with signs of pulmonary fibrosis and no symptoms of disease inflammatory activity had elevated blood IL-1 levels whereas an IL-1 receptor antagonist was decreased.
CONCLUSION: In the patients with PS, the development and progression of pulmonary fibrosis occur with a shift in the Th1/Th2 balance towards Th2, which manifests itself as a higher IL-4/IL-2 ratio in the peripheral blood. At the same time, the signs of systemic inflammatory activity remain.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:85 |
|---|---|
| Enthalten in: |
Terapevticheskii arkhiv - 85(2013), 3 vom: 16., Seite 23-7 |
| Sprache: |
Russisch |
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| Beteiligte Personen: |
Terpigorev, S A [VerfasserIn] |
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| Themen: |
207137-56-2 |
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| Anmerkungen: |
Date Completed 28.06.2013 Date Revised 30.05.2013 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM22791354X |
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| 245 | 1 | 0 | |a Change in the blood cytokine spectrum in patients with pulmonary sarcoidosis |
| 264 | 1 | |c 2013 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 28.06.2013 | ||
| 500 | |a Date Revised 30.05.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: To assess cytokine spectrum changes in different types of pulmonary sarcoidosis (PS) | ||
| 520 | |a SUBJECTS AND METHODS: Twenty-seven PS patients without signs of pulmonary fibrosis and 14 patients with sarcoidosis complicated by pulmonary fibrosis were examined. Baseline serum Th1 and Th2 cytokine concentrations were studied. A control group comprised 30 healthy donors | ||
| 520 | |a RESULTS: A higher interleukin (IL)-4/IL-2 ratio was found in the peripheral blood of the patients with pulmonary fibrosis-complicated sarcoidosis than in the other patients (326.4 +/- 122.6 and 88.2 +/- 28.6%, respectively; p = 0.002). The sarcoidosis patients with signs of pulmonary fibrosis and no symptoms of disease inflammatory activity had elevated blood IL-1 levels whereas an IL-1 receptor antagonist was decreased | ||
| 520 | |a CONCLUSION: In the patients with PS, the development and progression of pulmonary fibrosis occur with a shift in the Th1/Th2 balance towards Th2, which manifests itself as a higher IL-4/IL-2 ratio in the peripheral blood. At the same time, the signs of systemic inflammatory activity remain | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a Inflammation Mediators |2 NLM | |
| 650 | 7 | |a Interleukin-2 |2 NLM | |
| 650 | 7 | |a Interleukin-4 |2 NLM | |
| 650 | 7 | |a 207137-56-2 |2 NLM | |
| 700 | 1 | |a Novikov, A A |e verfasserin |4 aut | |
| 700 | 1 | |a El-Zein, B A |e verfasserin |4 aut | |
| 700 | 1 | |a Aleksandrova, E H |e verfasserin |4 aut | |
| 700 | 1 | |a Iazdovskiĭ, V V |e verfasserin |4 aut | |
| 700 | 1 | |a Moskalets, O V |e verfasserin |4 aut | |
| 700 | 1 | |a Paleev, F N |e verfasserin |4 aut | |
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