Against all odds : anti-IgE for intrinsic asthma?
For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:69 |
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| Enthalten in: |
Thorax - 69(2014), 1 vom: 01. Jan., Seite 94-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lommatzsch, Marek [VerfasserIn] |
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| Links: |
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| Themen: |
2P471X1Z11 |
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| Anmerkungen: |
Date Completed 26.03.2014 Date Revised 21.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1136/thoraxjnl-2013-203738 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM227811623 |
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| 245 | 1 | 0 | |a Against all odds |b anti-IgE for intrinsic asthma? |
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| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Asthma | |
| 650 | 4 | |a Asthma Mechanisms | |
| 650 | 4 | |a Asthma Pharmacology | |
| 650 | 7 | |a Anti-Asthmatic Agents |2 NLM | |
| 650 | 7 | |a Antibodies, Anti-Idiotypic |2 NLM | |
| 650 | 7 | |a Antibodies, Monoclonal, Humanized |2 NLM | |
| 650 | 7 | |a Omalizumab |2 NLM | |
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| 650 | 7 | |a Intrinsic Factor |2 NLM | |
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| 700 | 1 | |a Korn, Stephanie |e verfasserin |4 aut | |
| 700 | 1 | |a Buhl, Roland |e verfasserin |4 aut | |
| 700 | 1 | |a Virchow, Johann Christian |e verfasserin |4 aut | |
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