Human B-1 cells take the stage
© 2013 New York Academy of Sciences..
B-1 cells play critical roles in defending against microbial invasion and in housekeeping removal of cellular debris. B-1 cells secrete natural antibody and manifest functions that influence T cell expansion and differentiation and in these and other ways differ from conventional B-2 cells. B-1 cells were originally studied in mice where they are easily distinguished from B-2 cells, but their identity in the human system remained poorly defined for many years. Recently, functional criteria for human B-1 cells were established on the basis of murine findings, and reverse engineering resulted in identification of the phenotypic profile, CD20(+)CD27(+)CD43(+)CD70(-), for B-1 cells found in both umbilical cord blood and adult peripheral blood. Human B-1 cells may contribute to multiple disease states through production of autoantibody and stimulation/modulation of T cell activity. Human B-1 cells could be a rich source of antibodies useful in treating diseases present in elderly populations where natural antibody protection may have eroded. Manipulation of human B-1 cell numbers and/or activity may be a new avenue for altering T cell function and treating immune dyscrasias.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2013 |
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Erschienen: |
2013 |
Enthalten in: |
Zur Gesamtaufnahme - volume:1285 |
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Enthalten in: |
Annals of the New York Academy of Sciences - 1285(2013) vom: 05. Mai, Seite 97-114 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Rothstein, Thomas L [VerfasserIn] |
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Date Completed 02.08.2013 Date Revised 10.03.2022 published: Print Citation Status MEDLINE |
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doi: |
10.1111/nyas.12137 |
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funding: |
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PPN (Katalog-ID): |
NLM227675762 |
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