Rate of progression of CT-quantified emphysema in male current and ex-smokers : a follow-up study
BACKGROUND: Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers.
METHODS: 3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up. Smoking status (quitted ≥5, ≥1-<5, <1 years or current smoker) was noted. Rate of progression of emphysema and FEV1-decline after follow-up were assessed by analysis of variance adjusting for age, height, baseline pulmonary function and emphysema severity, packyears, years in study and respiratory symptoms. The quitted ≥5 group was used as reference.
RESULTS: Median (Q1-Q3) emphysema severity,<-950 HU, was 8.8 (5.1 - 14.1) and mean (SD) FEV1 was 3.4 (0.73) L or 98.5 (18.5) % of predicted. The group quitted '>5 years' showed significantly lower rates of progression of emphysema compared to current smokers, 1.07% and 1.12% per year, respectively (p<0.001). Current smokers had a yearly FEV1-decline of 69 ml, while subjects quit smoking >5 years had a yearly decline of 57.5 ml (p<0.001).
CONCLUSION: Quit smoking >5 years significantly slows the rate of emphysema progression and lung function decline.
TRIAL REGISTRATION: Registered at http://www.trialregister.nl with trial number ISRCTN63545820.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Respiratory research - 14(2013) vom: 20. Mai, Seite 55 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mohamed Hoesein, Firdaus A A [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 30.09.2013 Date Revised 21.10.2021 published: Electronic ISRCTN: ISRCTN63545820 Citation Status MEDLINE |
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| doi: |
10.1186/1465-9921-14-55 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM227632486 |
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| 100 | 1 | |a Mohamed Hoesein, Firdaus A A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Rate of progression of CT-quantified emphysema in male current and ex-smokers |b a follow-up study |
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| 500 | |a published: Electronic | ||
| 500 | |a ISRCTN: ISRCTN63545820 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers | ||
| 520 | |a METHODS: 3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up. Smoking status (quitted ≥5, ≥1-<5, <1 years or current smoker) was noted. Rate of progression of emphysema and FEV1-decline after follow-up were assessed by analysis of variance adjusting for age, height, baseline pulmonary function and emphysema severity, packyears, years in study and respiratory symptoms. The quitted ≥5 group was used as reference | ||
| 520 | |a RESULTS: Median (Q1-Q3) emphysema severity,<-950 HU, was 8.8 (5.1 - 14.1) and mean (SD) FEV1 was 3.4 (0.73) L or 98.5 (18.5) % of predicted. The group quitted '>5 years' showed significantly lower rates of progression of emphysema compared to current smokers, 1.07% and 1.12% per year, respectively (p<0.001). Current smokers had a yearly FEV1-decline of 69 ml, while subjects quit smoking >5 years had a yearly decline of 57.5 ml (p<0.001) | ||
| 520 | |a CONCLUSION: Quit smoking >5 years significantly slows the rate of emphysema progression and lung function decline | ||
| 520 | |a TRIAL REGISTRATION: Registered at http://www.trialregister.nl with trial number ISRCTN63545820 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 700 | 1 | |a Zanen, Pieter |e verfasserin |4 aut | |
| 700 | 1 | |a de Jong, Pim A |e verfasserin |4 aut | |
| 700 | 1 | |a van Ginneken, Bram |e verfasserin |4 aut | |
| 700 | 1 | |a Boezen, H Marike |e verfasserin |4 aut | |
| 700 | 1 | |a Groen, Harry J M |e verfasserin |4 aut | |
| 700 | 1 | |a Oudkerk, Mathijs |e verfasserin |4 aut | |
| 700 | 1 | |a de Koning, Harry J |e verfasserin |4 aut | |
| 700 | 1 | |a Postma, Dirkje S |e verfasserin |4 aut | |
| 700 | 1 | |a Lammers, Jan-Willem J |e verfasserin |4 aut | |
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