Distinctive profile of sudden cardiac arrest in middle-aged vs. older adults : a community-based study
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved..
BACKGROUND: While sudden cardiac arrest (SCA) rates increase with age, middle-aged adults (35-59 years) may comprise a significant proportion of SCA cases in the community (30-40%). However, there is a lack of studies evaluating SCA risk factors specifically associated with this age-group of the population.
METHODS: Using prospective multiple-source surveillance methodology we identified cases of SCA ≥35 years in the ongoing Oregon Sudden Unexpected Death Study (Portland, Oregon metropolitan area, population≈1,000,000). Out-of-hospital SCA cases, aged 35-59 years were compared to older SCA cases (≥60 years) in a comprehensive analysis of clinical profile of SCA.
RESULTS: The middle-aged (n=753) compared to older (n=1251) cases were more likely to be male, obese, have sleep apnea and seizure disorder (all p≤0.001); and were less likely to have a history of hypertension, diabetes mellitus, known coronary artery disease, congestive heart failure and syncope (all p<0.01). In multivariable analyses the middle-aged group had higher likelihood of male sex (O.R. 1.67, 95% C.I. 1.29-2.18), obesity (2.20, 1.52-3.19), sleep apnea (2.30, 1.44-3.68) and seizure disorder (2.69, 1.64-4.42); and lower rates of known coronary artery disease (0.57, 0.43-0.74) and congestive heart failure (0.35, 0.25-0.48).
CONCLUSIONS: SCA in the middle-aged adult was distinguishable from older subjects by higher rates of obesity, sleep apnea and seizure disorder; and lower prevalence of traditional clinical risk markers. With the growing epidemic of obesity, these findings have implications for SCA burden; and suggest the need for a clinical and investigational focus on SCA prediction and prevention in the middle-aged adult, that is distinct from older adults.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:168 |
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| Enthalten in: |
International journal of cardiology - 168(2013), 4 vom: 09. Okt., Seite 3495-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Noheria, Amit [VerfasserIn] |
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| Links: |
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| Themen: |
Community |
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| Anmerkungen: |
Date Completed 26.06.2014 Date Revised 21.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2013.04.207 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM227598822 |
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| 100 | 1 | |a Noheria, Amit |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Distinctive profile of sudden cardiac arrest in middle-aged vs. older adults |b a community-based study |
| 264 | 1 | |c 2013 | |
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| 500 | |a Date Completed 26.06.2014 | ||
| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: While sudden cardiac arrest (SCA) rates increase with age, middle-aged adults (35-59 years) may comprise a significant proportion of SCA cases in the community (30-40%). However, there is a lack of studies evaluating SCA risk factors specifically associated with this age-group of the population | ||
| 520 | |a METHODS: Using prospective multiple-source surveillance methodology we identified cases of SCA ≥35 years in the ongoing Oregon Sudden Unexpected Death Study (Portland, Oregon metropolitan area, population≈1,000,000). Out-of-hospital SCA cases, aged 35-59 years were compared to older SCA cases (≥60 years) in a comprehensive analysis of clinical profile of SCA | ||
| 520 | |a RESULTS: The middle-aged (n=753) compared to older (n=1251) cases were more likely to be male, obese, have sleep apnea and seizure disorder (all p≤0.001); and were less likely to have a history of hypertension, diabetes mellitus, known coronary artery disease, congestive heart failure and syncope (all p<0.01). In multivariable analyses the middle-aged group had higher likelihood of male sex (O.R. 1.67, 95% C.I. 1.29-2.18), obesity (2.20, 1.52-3.19), sleep apnea (2.30, 1.44-3.68) and seizure disorder (2.69, 1.64-4.42); and lower rates of known coronary artery disease (0.57, 0.43-0.74) and congestive heart failure (0.35, 0.25-0.48) | ||
| 520 | |a CONCLUSIONS: SCA in the middle-aged adult was distinguishable from older subjects by higher rates of obesity, sleep apnea and seizure disorder; and lower prevalence of traditional clinical risk markers. With the growing epidemic of obesity, these findings have implications for SCA burden; and suggest the need for a clinical and investigational focus on SCA prediction and prevention in the middle-aged adult, that is distinct from older adults | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Community | |
| 650 | 4 | |a Coronary artery disease | |
| 650 | 4 | |a Middle-age | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a Sudden-death | |
| 700 | 1 | |a Teodorescu, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Uy-Evanado, Audrey |e verfasserin |4 aut | |
| 700 | 1 | |a Reinier, Kyndaron |e verfasserin |4 aut | |
| 700 | 1 | |a Mariani, Ronald |e verfasserin |4 aut | |
| 700 | 1 | |a Gunson, Karen |e verfasserin |4 aut | |
| 700 | 1 | |a Jui, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Chugh, Sumeet S |e verfasserin |4 aut | |
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