Hepcidin as a predictor of disease severity in acute pancreatitis : a single center prospective study
BACKGROUND/AIMS: Predicting the severity of acute pancreatitis is limited to clinical, laboratory and radiological risk factors. Hepcidin levels increase in acute inflammation. We aimed to assess the relationship between hepcidin and C-reactive protein (CRP), white blood cells (WBC) and multi-detector computerized tomography (MDCT) in predicting the severity of pancreatitis.
METHODOLOGY: We undertook a prospective review of 59 consecutive patients with acute pancreatitis admitted to our clinic. Biochemical values were measured from blood samples taken within 2 hours of admission and from between 2 and 72 hours related to the time of symptom onset.
RESULTS: In predicting severe acute pancreatitis, hepcidin was superior to CRP and WBC (Area Under the Curve (AUC)=0.79, p=0.003; AUC=0.69, p=NS; AUC=0.53, p=NS, respectively).
CONCLUSIONS: In this study, hepcidin was found to be superior to CRP in predicting the severity of pancreatitis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Hepato-gastroenterology - 60(2013), 123 vom: 02. Mai, Seite 595-600 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Arabul, Mahmut [VerfasserIn] |
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| Links: |
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| Themen: |
9007-41-4 |
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| Anmerkungen: |
Date Completed 25.09.2013 Date Revised 25.11.2016 published: Print Citation Status MEDLINE |
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| doi: |
10.5754/hge12770 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM227416686 |
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| 245 | 1 | 0 | |a Hepcidin as a predictor of disease severity in acute pancreatitis |b a single center prospective study |
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| 500 | |a Date Completed 25.09.2013 | ||
| 500 | |a Date Revised 25.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND/AIMS: Predicting the severity of acute pancreatitis is limited to clinical, laboratory and radiological risk factors. Hepcidin levels increase in acute inflammation. We aimed to assess the relationship between hepcidin and C-reactive protein (CRP), white blood cells (WBC) and multi-detector computerized tomography (MDCT) in predicting the severity of pancreatitis | ||
| 520 | |a METHODOLOGY: We undertook a prospective review of 59 consecutive patients with acute pancreatitis admitted to our clinic. Biochemical values were measured from blood samples taken within 2 hours of admission and from between 2 and 72 hours related to the time of symptom onset | ||
| 520 | |a RESULTS: In predicting severe acute pancreatitis, hepcidin was superior to CRP and WBC (Area Under the Curve (AUC)=0.79, p=0.003; AUC=0.69, p=NS; AUC=0.53, p=NS, respectively) | ||
| 520 | |a CONCLUSIONS: In this study, hepcidin was found to be superior to CRP in predicting the severity of pancreatitis | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Ünsal, Belkis |e verfasserin |4 aut | |
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