HLA-B27 predicts a more chronic disease course in an 8-year followup cohort of patients with juvenile idiopathic arthritis
OBJECTIVE: We investigated associations of HLA-B27 with clinical manifestations and longterm outcome in a near population-based setting among patients with juvenile idiopathic arthritis (JIA).
METHODS: We studied clinical and serological data from 410 patients with HLA-B27 results among 440 prospectively collected patients with JIA with 8-year followup data in a Nordic database. The study was structured to be as close to a population-based study as possible.
RESULTS: HLA-B27 was analyzed in 93% of patients, and was positive in 21% of the cohort, in 18.4% of the girls and in 25.9% of the boys. Boys who were HLA-B27-positive had significantly higher age at onset compared to HLA-B27-negative boys and compared to both HLA-B27-negative and positive girls. This difference in onset age in relation to HLA-B27 was not found in girls. HLA-B27 was associated with clinical signs of sacroiliitis, enthesitis, and tenosynovitis in boys, but not in girls. After 8 years of disease, 46 children (11.2%) were classified as having enthesitis-related arthritis (ERA). Boys with ERA had clinical signs of sacroiliitis more often than girls with ERA. HLA-B27-positive children, as well as children with clinical signs of sacroiliitis, enthesitis, and hip arthritis, had higher odds of not being in remission off medication after 8 years of disease.
CONCLUSION: In this near population-based Nordic JIA cohort we found significant differences between HLA-B27-positive boys and girls in age at disease onset, clinical signs of sacroiliitis, and ERA classification. HLA-B27 was negatively associated with longterm remission status, possibly because of its association with clinical disease characteristics, such as sacroiliitis, rather than being a general marker of persistent disease.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2013 |
---|---|
Erschienen: |
2013 |
Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
---|---|
Enthalten in: |
The Journal of rheumatology - 40(2013), 5 vom: 01. Mai, Seite 725-31 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Berntson, Lillemor [VerfasserIn] |
---|
Links: |
---|
Themen: |
CHILD |
---|
Anmerkungen: |
Date Completed 10.12.2013 Date Revised 20.11.2014 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.3899/jrheum.121257 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM226305503 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM226305503 | ||
003 | DE-627 | ||
005 | 20231224071134.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231224s2013 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3899/jrheum.121257 |2 doi | |
028 | 5 | 2 | |a pubmed24n0754.xml |
035 | |a (DE-627)NLM226305503 | ||
035 | |a (NLM)23547219 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Berntson, Lillemor |e verfasserin |4 aut | |
245 | 1 | 0 | |a HLA-B27 predicts a more chronic disease course in an 8-year followup cohort of patients with juvenile idiopathic arthritis |
264 | 1 | |c 2013 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 10.12.2013 | ||
500 | |a Date Revised 20.11.2014 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a OBJECTIVE: We investigated associations of HLA-B27 with clinical manifestations and longterm outcome in a near population-based setting among patients with juvenile idiopathic arthritis (JIA) | ||
520 | |a METHODS: We studied clinical and serological data from 410 patients with HLA-B27 results among 440 prospectively collected patients with JIA with 8-year followup data in a Nordic database. The study was structured to be as close to a population-based study as possible | ||
520 | |a RESULTS: HLA-B27 was analyzed in 93% of patients, and was positive in 21% of the cohort, in 18.4% of the girls and in 25.9% of the boys. Boys who were HLA-B27-positive had significantly higher age at onset compared to HLA-B27-negative boys and compared to both HLA-B27-negative and positive girls. This difference in onset age in relation to HLA-B27 was not found in girls. HLA-B27 was associated with clinical signs of sacroiliitis, enthesitis, and tenosynovitis in boys, but not in girls. After 8 years of disease, 46 children (11.2%) were classified as having enthesitis-related arthritis (ERA). Boys with ERA had clinical signs of sacroiliitis more often than girls with ERA. HLA-B27-positive children, as well as children with clinical signs of sacroiliitis, enthesitis, and hip arthritis, had higher odds of not being in remission off medication after 8 years of disease | ||
520 | |a CONCLUSION: In this near population-based Nordic JIA cohort we found significant differences between HLA-B27-positive boys and girls in age at disease onset, clinical signs of sacroiliitis, and ERA classification. HLA-B27 was negatively associated with longterm remission status, possibly because of its association with clinical disease characteristics, such as sacroiliitis, rather than being a general marker of persistent disease | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a CHILD | |
650 | 4 | |a GENETICS | |
650 | 4 | |a HLA-B27 | |
650 | 4 | |a JOINTS | |
650 | 4 | |a JUVENILE RHEUMATOID ARTHRITIS | |
650 | 7 | |a HLA-B27 Antigen |2 NLM | |
700 | 1 | |a Nordal, Ellen |e verfasserin |4 aut | |
700 | 1 | |a Aalto, Kristiina |e verfasserin |4 aut | |
700 | 1 | |a Peltoniemi, Suvi |e verfasserin |4 aut | |
700 | 1 | |a Herlin, Troels |e verfasserin |4 aut | |
700 | 1 | |a Zak, Marek |e verfasserin |4 aut | |
700 | 1 | |a Nielsen, Susan |e verfasserin |4 aut | |
700 | 1 | |a Rygg, Marite |e verfasserin |4 aut | |
700 | 0 | |a Nordic Study Group of Paediatric Rheumatology |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t The Journal of rheumatology |d 1983 |g 40(2013), 5 vom: 01. Mai, Seite 725-31 |w (DE-627)NLM000019593 |x 1499-2752 |7 nnns |
773 | 1 | 8 | |g volume:40 |g year:2013 |g number:5 |g day:01 |g month:05 |g pages:725-31 |
856 | 4 | 0 | |u http://dx.doi.org/10.3899/jrheum.121257 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 40 |j 2013 |e 5 |b 01 |c 05 |h 725-31 |