Plasma renin-angiotensin system-regulating aminopeptidase activities are modified in early stage Alzheimer's disease and show gender differences but are not related to apolipoprotein E genotype
Copyright © 2013 Elsevier Inc. All rights reserved..
Alterations in blood pressure and components of the renin-angiotensin system (RAS) contribute to the development and progression of Alzheimer's disease (AD), resulting in changes that can lead or contribute to cognitive decline. Aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase N (APN) and aminopeptidase B (APB) catabolise circulating angiotensins, whereas insulin-regulated aminopeptidase (IRAP) has been described as the AT4 receptor. We have found in AD patients a significant decrease of APA activity in men but not in women, and of APN, APB and IRAP in both genders, when compared with control subjects. No changes were found in ASAP activity. Also, APN, APB and IRAP but not APA correlated with the Mini-Mental test, but no relationship with APOE genotype was found. We conclude that several components of the RAS are modified in AD patients, with gender differences. Furthermore, ROC analysis indicates that APN, APB and IRAP activities could be useful non-invasive biomarkers of AD from the earliest stages.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2013 |
|---|---|
| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
|---|---|
| Enthalten in: |
Experimental gerontology - 48(2013), 6 vom: 01. Juni, Seite 557-64 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Puertas, María Del Carmen [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 07.11.2013 Date Revised 09.04.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.exger.2013.03.002 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM225877864 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM225877864 | ||
| 003 | DE-627 | ||
| 005 | 20231224070148.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.exger.2013.03.002 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0753.xml |
| 035 | |a (DE-627)NLM225877864 | ||
| 035 | |a (NLM)23500679 | ||
| 035 | |a (PII)S0531-5565(13)00079-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Puertas, María Del Carmen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Plasma renin-angiotensin system-regulating aminopeptidase activities are modified in early stage Alzheimer's disease and show gender differences but are not related to apolipoprotein E genotype |
| 264 | 1 | |c 2013 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 07.11.2013 | ||
| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2013 Elsevier Inc. All rights reserved. | ||
| 520 | |a Alterations in blood pressure and components of the renin-angiotensin system (RAS) contribute to the development and progression of Alzheimer's disease (AD), resulting in changes that can lead or contribute to cognitive decline. Aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase N (APN) and aminopeptidase B (APB) catabolise circulating angiotensins, whereas insulin-regulated aminopeptidase (IRAP) has been described as the AT4 receptor. We have found in AD patients a significant decrease of APA activity in men but not in women, and of APN, APB and IRAP in both genders, when compared with control subjects. No changes were found in ASAP activity. Also, APN, APB and IRAP but not APA correlated with the Mini-Mental test, but no relationship with APOE genotype was found. We conclude that several components of the RAS are modified in AD patients, with gender differences. Furthermore, ROC analysis indicates that APN, APB and IRAP activities could be useful non-invasive biomarkers of AD from the earliest stages | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a AT4 receptor |2 NLM | |
| 650 | 7 | |a Apolipoproteins E |2 NLM | |
| 650 | 7 | |a Receptors, Angiotensin |2 NLM | |
| 650 | 7 | |a Aminopeptidases |2 NLM | |
| 650 | 7 | |a EC 3.4.11.- |2 NLM | |
| 650 | 7 | |a CD13 Antigens |2 NLM | |
| 650 | 7 | |a EC 3.4.11.2 |2 NLM | |
| 650 | 7 | |a Cystinyl Aminopeptidase |2 NLM | |
| 650 | 7 | |a EC 3.4.11.3 |2 NLM | |
| 650 | 7 | |a leucyl-cystinyl aminopeptidase |2 NLM | |
| 650 | 7 | |a EC 3.4.11.3 |2 NLM | |
| 650 | 7 | |a aminopeptidase B |2 NLM | |
| 650 | 7 | |a EC 3.4.11.6 |2 NLM | |
| 650 | 7 | |a Glutamyl Aminopeptidase |2 NLM | |
| 650 | 7 | |a EC 3.4.11.7 |2 NLM | |
| 700 | 1 | |a Martínez-Martos, José Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Cobo, Manuela |e verfasserin |4 aut | |
| 700 | 1 | |a Lorite, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Sandalio, Rosa María |e verfasserin |4 aut | |
| 700 | 1 | |a Palomeque, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Torres, María Isabel |e verfasserin |4 aut | |
| 700 | 1 | |a Carrera-González, María Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Mayas, María Dolores |e verfasserin |4 aut | |
| 700 | 1 | |a Ramírez-Expósito, María Jesús |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Experimental gerontology |d 1968 |g 48(2013), 6 vom: 01. Juni, Seite 557-64 |w (DE-627)NLM000016608 |x 1873-6815 |7 nnns |
| 773 | 1 | 8 | |g volume:48 |g year:2013 |g number:6 |g day:01 |g month:06 |g pages:557-64 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.exger.2013.03.002 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 48 |j 2013 |e 6 |b 01 |c 06 |h 557-64 | ||