Mannose-binding lectin and susceptibility to schistosomiasis
BACKGROUND: Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis.
METHODS: We used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium-infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis.
RESULTS: MBL serum levels were significantly higher in controls and were associated with protection (P < .0001). The -550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes -550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03).
CONCLUSIONS: In agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:207 |
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| Enthalten in: |
The Journal of infectious diseases - 207(2013), 11 vom: 01. Juni, Seite 1675-83 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Antony, Justin S [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 28.06.2013 Date Revised 21.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jit081 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM225399520 |
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| 100 | 1 | |a Antony, Justin S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mannose-binding lectin and susceptibility to schistosomiasis |
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| 500 | |a Date Completed 28.06.2013 | ||
| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis | ||
| 520 | |a METHODS: We used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium-infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis | ||
| 520 | |a RESULTS: MBL serum levels were significantly higher in controls and were associated with protection (P < .0001). The -550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes -550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03) | ||
| 520 | |a CONCLUSIONS: In agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a MBL2 protein, human |2 NLM | |
| 650 | 7 | |a Mannose-Binding Lectin |2 NLM | |
| 700 | 1 | |a Ojurongbe, Olusola |e verfasserin |4 aut | |
| 700 | 1 | |a van Tong, Hoang |e verfasserin |4 aut | |
| 700 | 1 | |a Ouf, Eman Abou |e verfasserin |4 aut | |
| 700 | 1 | |a Engleitner, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Akindele, Akeem A |e verfasserin |4 aut | |
| 700 | 1 | |a Sina-Agbaje, Olawumi R |e verfasserin |4 aut | |
| 700 | 1 | |a Adeyeba, Adegboyega O |e verfasserin |4 aut | |
| 700 | 1 | |a Kremsner, Peter G |e verfasserin |4 aut | |
| 700 | 1 | |a Velavan, Thirumalaisamy P |e verfasserin |4 aut | |
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