Tracing the cellular origin of cancer
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2013 |
|---|---|
| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
|---|---|
| Enthalten in: |
Nature cell biology - 15(2013), 2 vom: 07. Feb., Seite 126-34 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Blanpain, Cédric [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 29.03.2013 Date Revised 30.03.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/ncb2657 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM22431677X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM22431677X | ||
| 003 | DE-627 | ||
| 005 | 20231224062635.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/ncb2657 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0747.xml |
| 035 | |a (DE-627)NLM22431677X | ||
| 035 | |a (NLM)23334500 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Blanpain, Cédric |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tracing the cellular origin of cancer |
| 264 | 1 | |c 2013 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 29.03.2013 | ||
| 500 | |a Date Revised 30.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 773 | 0 | 8 | |i Enthalten in |t Nature cell biology |d 1999 |g 15(2013), 2 vom: 07. Feb., Seite 126-34 |w (DE-627)NLM104898879 |x 1476-4679 |7 nnns |
| 773 | 1 | 8 | |g volume:15 |g year:2013 |g number:2 |g day:07 |g month:02 |g pages:126-34 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/ncb2657 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 15 |j 2013 |e 2 |b 07 |c 02 |h 126-34 | ||