Neutraceutical approaches to control diabetes : A natural requisite approach
OBJECTIVE: The aim of this study is to screen the polyherbal preparation for antidiabetic activity in rats.
MATERIALS AND METHODS: The blood glucose lowering activity of the polyherbal preparation-I (1:1:1 of wheat germ oil, Coraidrum sativum, and Aloe vera) was studied in normal rats after oral administration at doses of 1.0 ml/kg and 2.0 ml/kg and polyherbal preparation-I, II (wheat germ oil, fresh juice of C. sativum, and A. vera in the ratio of 2:2:1), and III (wheat germ oil, fresh juice of C. sativum and A. vera in the ratio of 1:2:2) on alloxan-induced diabetic rats, after oral administration at doses of 1.0 ml/kg and 2.0 ml/kg. Blood samples were collected from the tail vein method at 0, 0.5, 1, 2, 4, 8, 12, and 24 h in normal rats and in diabetic rats at 0, 1, 3, 7, 15, and 30 days. Blood plasma glucose was estimated by the GOD/POD (glucose oxidase and peroxidase) method. The data were compared statistically by using the one-way ANOVA method followed by the Dunnett multiple component test. Statistical significance was set at P < 0.05.
RESULTS: The polyherbal preparation-I produced significant (P < 0.05) reduction in the blood glucose level of normal rats and polyherbal preparation-I, II, and III produced significant (P < 0.01) reduction in the blood glucose level of diabetic rats during 30-day study and compared with that of control and glibenclamide.
CONCLUSION: The polyherbal preparation-I showed a significant glucose lowering effect in normal rats and polyherbal preparation-I, II, and III in diabetic rats. This preparation is going to be promising antidiabetic preparation for masses; however, it requires further extensive studies in human beings.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
|---|---|
| Enthalten in: |
Journal of natural science, biology, and medicine - 3(2012), 2 vom: 15. Juli, Seite 168-76 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Srivastava, N [VerfasserIn] |
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| Links: |
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| Themen: |
Alloxan-induced diabetes |
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| Anmerkungen: |
Date Completed 12.12.2012 Date Revised 21.10.2021 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.4103/0976-9668.101904 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM223312274 |
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| 500 | |a Date Completed 12.12.2012 | ||
| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a OBJECTIVE: The aim of this study is to screen the polyherbal preparation for antidiabetic activity in rats | ||
| 520 | |a MATERIALS AND METHODS: The blood glucose lowering activity of the polyherbal preparation-I (1:1:1 of wheat germ oil, Coraidrum sativum, and Aloe vera) was studied in normal rats after oral administration at doses of 1.0 ml/kg and 2.0 ml/kg and polyherbal preparation-I, II (wheat germ oil, fresh juice of C. sativum, and A. vera in the ratio of 2:2:1), and III (wheat germ oil, fresh juice of C. sativum and A. vera in the ratio of 1:2:2) on alloxan-induced diabetic rats, after oral administration at doses of 1.0 ml/kg and 2.0 ml/kg. Blood samples were collected from the tail vein method at 0, 0.5, 1, 2, 4, 8, 12, and 24 h in normal rats and in diabetic rats at 0, 1, 3, 7, 15, and 30 days. Blood plasma glucose was estimated by the GOD/POD (glucose oxidase and peroxidase) method. The data were compared statistically by using the one-way ANOVA method followed by the Dunnett multiple component test. Statistical significance was set at P < 0.05 | ||
| 520 | |a RESULTS: The polyherbal preparation-I produced significant (P < 0.05) reduction in the blood glucose level of normal rats and polyherbal preparation-I, II, and III produced significant (P < 0.01) reduction in the blood glucose level of diabetic rats during 30-day study and compared with that of control and glibenclamide | ||
| 520 | |a CONCLUSION: The polyherbal preparation-I showed a significant glucose lowering effect in normal rats and polyherbal preparation-I, II, and III in diabetic rats. This preparation is going to be promising antidiabetic preparation for masses; however, it requires further extensive studies in human beings | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alloxan-induced diabetes | |
| 650 | 4 | |a blood plasma glucose level | |
| 650 | 4 | |a effect of polyherbal preparation | |
| 700 | 1 | |a Tiwari, G |e verfasserin |4 aut | |
| 700 | 1 | |a Tiwari, R |e verfasserin |4 aut | |
| 700 | 1 | |a Bhati, L K |e verfasserin |4 aut | |
| 700 | 1 | |a Rai, Awani K |e verfasserin |4 aut | |
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