Cardiovascular involvement in patients affected by acromegaly : an appraisal
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved..
Cardiovascular complications are frequent in acromegalic patients. Several studies reported increased prevalence of traditional cardiovascular risk factors and early development of endothelial dysfunction and of structural vascular alterations, with subsequent increased risk of coronary artery disease. Furthermore, chronic exposure to high levels of GH and IGF-I leads to the development of the so called "acromegalic cardiomyopathy", characterized by concentric biventricular hypertrophy, diastolic dysfunction and, additionally, by progressive impairment of systolic performance leading to overt heart failure. Cardiac valvulopathies and arrhythmias have also been documented and may concur to the deterioration of cardiac function. Together with strict control of cardiovascular risk factors, early control of GH and IGF-I excess, by surgical or pharmacological therapy, has been reported to ameliorate cardiac and metabolic abnormalities, leading to a significant reduction of left ventricular hypertrophy and to a consistent improvement of cardiac performance.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:167 |
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| Enthalten in: |
International journal of cardiology - 167(2013), 5 vom: 01. Sept., Seite 1712-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mosca, Susanna [VerfasserIn] |
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| Links: |
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| Themen: |
12629-01-5 |
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| Anmerkungen: |
Date Completed 22.04.2014 Date Revised 08.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2012.11.109 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM223246999 |
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| 520 | |a Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. | ||
| 520 | |a Cardiovascular complications are frequent in acromegalic patients. Several studies reported increased prevalence of traditional cardiovascular risk factors and early development of endothelial dysfunction and of structural vascular alterations, with subsequent increased risk of coronary artery disease. Furthermore, chronic exposure to high levels of GH and IGF-I leads to the development of the so called "acromegalic cardiomyopathy", characterized by concentric biventricular hypertrophy, diastolic dysfunction and, additionally, by progressive impairment of systolic performance leading to overt heart failure. Cardiac valvulopathies and arrhythmias have also been documented and may concur to the deterioration of cardiac function. Together with strict control of cardiovascular risk factors, early control of GH and IGF-I excess, by surgical or pharmacological therapy, has been reported to ameliorate cardiac and metabolic abnormalities, leading to a significant reduction of left ventricular hypertrophy and to a consistent improvement of cardiac performance | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Acromegalic cardiomyopathy | |
| 650 | 4 | |a Acromegaly | |
| 650 | 4 | |a GH/IGF-I excess | |
| 650 | 4 | |a Premature atherosclerosis | |
| 650 | 7 | |a Human Growth Hormone |2 NLM | |
| 650 | 7 | |a 12629-01-5 |2 NLM | |
| 700 | 1 | |a Paolillo, Stefania |e verfasserin |4 aut | |
| 700 | 1 | |a Colao, Annamaria |e verfasserin |4 aut | |
| 700 | 1 | |a Bossone, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Cittadini, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Iudice, Francesco Lo |e verfasserin |4 aut | |
| 700 | 1 | |a Parente, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Conte, Sirio |e verfasserin |4 aut | |
| 700 | 1 | |a Rengo, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Leosco, Dario |e verfasserin |4 aut | |
| 700 | 1 | |a Trimarco, Bruno |e verfasserin |4 aut | |
| 700 | 1 | |a Filardi, Pasquale Perrone |e verfasserin |4 aut | |
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