β-adrenergic receptors and G protein-coupled receptor kinase-2 in Alzheimer's disease : a new paradigm for prognosis and therapy?
Alzheimer's disease (AD) is a devastating form of dementia that imposes a severe burden on health systems and society. Although several aspects of AD pathogenesis have been elucidated over the last few decades, many questions still need to be addressed. In fact, currently available medications only provide symptomatic improvement in patients with AD without affecting disease progression. The β-adrenergic receptor (β-AR) system can be considered a possible target that deserves further exploration in AD. The central noradrenergic system undergoes substantial changes in the course of AD and β-ARs have been implicated not only in amyloid formation in AD brain but also in amyloid-induced neurotoxicity. Moreover, clinical evidence suggests a protective role of β-AR blockers on AD onset. In addition to that, post-receptor components of β-AR signaling seem to have a role in AD pathogenesis. In particular, the G protein coupled receptor kinase 2, responsible for β-AR desensitization and downregulation, mediates amyloid-induced β-AR dysfunction in neurons, and its levels in circulating lymphocytes of AD patients are increased and inversely correlated with patient's cognitive status. Therefore, there is an urgent need to gain further insight on the role of the adrenergic system components in AD pathogenesis in order to translate preclinical and clinical knowledge to more efficacious prognostic and therapeutic strategies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Journal of Alzheimer's disease : JAD - 34(2013), 2 vom: 28., Seite 341-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Femminella, Grazia Daniela [VerfasserIn] |
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| Links: |
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| Themen: |
Adrenergic Agents |
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| Anmerkungen: |
Date Completed 29.10.2013 Date Revised 25.11.2016 published: Print Citation Status MEDLINE |
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| doi: |
10.3233/JAD-121813 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM223137154 |
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| 100 | 1 | |a Femminella, Grazia Daniela |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a β-adrenergic receptors and G protein-coupled receptor kinase-2 in Alzheimer's disease |b a new paradigm for prognosis and therapy? |
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| 500 | |a Date Completed 29.10.2013 | ||
| 500 | |a Date Revised 25.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Alzheimer's disease (AD) is a devastating form of dementia that imposes a severe burden on health systems and society. Although several aspects of AD pathogenesis have been elucidated over the last few decades, many questions still need to be addressed. In fact, currently available medications only provide symptomatic improvement in patients with AD without affecting disease progression. The β-adrenergic receptor (β-AR) system can be considered a possible target that deserves further exploration in AD. The central noradrenergic system undergoes substantial changes in the course of AD and β-ARs have been implicated not only in amyloid formation in AD brain but also in amyloid-induced neurotoxicity. Moreover, clinical evidence suggests a protective role of β-AR blockers on AD onset. In addition to that, post-receptor components of β-AR signaling seem to have a role in AD pathogenesis. In particular, the G protein coupled receptor kinase 2, responsible for β-AR desensitization and downregulation, mediates amyloid-induced β-AR dysfunction in neurons, and its levels in circulating lymphocytes of AD patients are increased and inversely correlated with patient's cognitive status. Therefore, there is an urgent need to gain further insight on the role of the adrenergic system components in AD pathogenesis in order to translate preclinical and clinical knowledge to more efficacious prognostic and therapeutic strategies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Adrenergic Agents |2 NLM | |
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| 700 | 1 | |a Pagano, Gennaro |e verfasserin |4 aut | |
| 700 | 1 | |a de Lucia, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Komici, Klara |e verfasserin |4 aut | |
| 700 | 1 | |a Parisi, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Cannavo, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Liccardo, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Vigorito, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Filardi, Pasquale Perrone |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrara, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Leosco, Dario |e verfasserin |4 aut | |
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