Urinary iodine is associated with insulin resistance in subjects with diabetes mellitus type 2
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York..
BACKGROUND: Diabetes Mellitus (DM) is a major health problem worldwide and its prevalence in Saudi Arabia has reached 31.6%. Patients with diabetes mellitus are at an increased risk of thyroid disease. The purpose of this study was to examine the urinary excretion of iodine in type 2 DM (T2DM) patients, and to assess the clinical implication of iodine status on T2DM.
METHODS: A total of 266 adult Saudis aged 18-55 years (109 T2DM patients and 157 healthy controls) were randomly selected from the Riyadh Cohort Study. Subjects were assessed for anthropometry, morning blood chemistries including fasting glucose, and lipid profile; serum concentrations of leptin, adiponectin, resistin, insulin, aPAI, hsCRP, Ang II, TNF-α, TSH, T3, T4, urine creatinine, urine iodine were measured using specific assays.
RESULTS: The concentration of urine iodine was significantly lower in T2DM than in healthy control subjects (84.6±2.3 vs. 119.4±3.4, p<0.001), which remained significant after creatinine correction and controlling for age (p=0.01). Furthermore, urinary iodine is negatively correlated with waist, hips, SAD, glucose, insulin, HOMA-IR triglyceride, resistin, angiotensin II (Ang II), and CRP, while it was positively associated with TSH.
CONCLUSIONS: The decreased levels of iodine concentration in T2DM patients and its likely deleterious effects on metabolic functions calls for a systematic approach to thyroid disease screening in diabetic patients. Routine annual urinary iodine determination is recommended and should target T2DM patients at risk of thyroid dysfunction.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:120 |
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| Enthalten in: |
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 120(2012), 10 vom: 21. Nov., Seite 618-22 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Al-Attas, O S [VerfasserIn] |
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| Anmerkungen: |
Date Completed 03.05.2013 Date Revised 21.11.2013 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1055/s-0032-1323816 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM223096350 |
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| 245 | 1 | 0 | |a Urinary iodine is associated with insulin resistance in subjects with diabetes mellitus type 2 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York. | ||
| 520 | |a BACKGROUND: Diabetes Mellitus (DM) is a major health problem worldwide and its prevalence in Saudi Arabia has reached 31.6%. Patients with diabetes mellitus are at an increased risk of thyroid disease. The purpose of this study was to examine the urinary excretion of iodine in type 2 DM (T2DM) patients, and to assess the clinical implication of iodine status on T2DM | ||
| 520 | |a METHODS: A total of 266 adult Saudis aged 18-55 years (109 T2DM patients and 157 healthy controls) were randomly selected from the Riyadh Cohort Study. Subjects were assessed for anthropometry, morning blood chemistries including fasting glucose, and lipid profile; serum concentrations of leptin, adiponectin, resistin, insulin, aPAI, hsCRP, Ang II, TNF-α, TSH, T3, T4, urine creatinine, urine iodine were measured using specific assays | ||
| 520 | |a RESULTS: The concentration of urine iodine was significantly lower in T2DM than in healthy control subjects (84.6±2.3 vs. 119.4±3.4, p<0.001), which remained significant after creatinine correction and controlling for age (p=0.01). Furthermore, urinary iodine is negatively correlated with waist, hips, SAD, glucose, insulin, HOMA-IR triglyceride, resistin, angiotensin II (Ang II), and CRP, while it was positively associated with TSH | ||
| 520 | |a CONCLUSIONS: The decreased levels of iodine concentration in T2DM patients and its likely deleterious effects on metabolic functions calls for a systematic approach to thyroid disease screening in diabetic patients. Routine annual urinary iodine determination is recommended and should target T2DM patients at risk of thyroid dysfunction | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Iodine |2 NLM | |
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| 700 | 1 | |a Al-Daghri, N M |e verfasserin |4 aut | |
| 700 | 1 | |a Alkharfy, K M |e verfasserin |4 aut | |
| 700 | 1 | |a Alokail, M S |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Johani, N J |e verfasserin |4 aut | |
| 700 | 1 | |a Abd-Alrahman, S H |e verfasserin |4 aut | |
| 700 | 1 | |a Yakout, S M |e verfasserin |4 aut | |
| 700 | 1 | |a Draz, H M |e verfasserin |4 aut | |
| 700 | 1 | |a Sabico, S |e verfasserin |4 aut | |
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