Association between body mass index and pregnancy outcome in a randomized trial of cerclage for short cervix
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd..
OBJECTIVE: To evaluate whether increasing body mass index (BMI) alters the efficacy of ultrasound-directed cerclage in women with a history of preterm birth.
METHODS: This was a planned secondary analysis of a multicenter trial in which women with a singleton gestation and prior spontaneous preterm birth (17 to 33 + 6 weeks' gestation) were screened for a short cervix by serial transvaginal ultrasound evaluations between 16 and 22 + 6 weeks. Women with a short cervix (cervical length < 25 mm) were randomly assigned to cerclage or not. Linear and logistic regression were used to assess the relationship between BMI and continuous and categorical variables, respectively.
RESULTS: Overall, in the screened women (n = 986), BMI was not associated with cervical length (P = 0.68), gestational age at delivery (P = 0.12) or birth at < 35 weeks (P = 0.68). For the cerclage group (n = 148), BMI had no significant effect. For the no-cerclage group (n = 153), BMI was associated with a decrease in gestational age at delivery, with an estimated slope of - 0.14 weeks per kg/m(2) (P = 0.03; including adjustment for cervical length). This result was driven primarily by several women with BMI > 47 kg/m(2).
CONCLUSION: In women at high risk for recurrent preterm birth, BMI was not associated with cervical length or gestational age at birth. BMI did not appear to adversely affect ultrasound-indicated cerclage.
| Errataetall: |
CommentIn: Ultrasound Obstet Gynecol. 2012 Dec;40(6):619. - PMID 23192993 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology - 40(2012), 6 vom: 06. Dez., Seite 669-73 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Farinelli, C K [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 06.05.2013 Date Revised 20.10.2023 published: Print CommentIn: Ultrasound Obstet Gynecol. 2012 Dec;40(6):619. - PMID 23192993 Citation Status MEDLINE |
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| doi: |
10.1002/UOG.11170 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM222997222 |
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| 100 | 1 | |a Farinelli, C K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association between body mass index and pregnancy outcome in a randomized trial of cerclage for short cervix |
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| 500 | |a Date Revised 20.10.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Ultrasound Obstet Gynecol. 2012 Dec;40(6):619. - PMID 23192993 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. | ||
| 520 | |a OBJECTIVE: To evaluate whether increasing body mass index (BMI) alters the efficacy of ultrasound-directed cerclage in women with a history of preterm birth | ||
| 520 | |a METHODS: This was a planned secondary analysis of a multicenter trial in which women with a singleton gestation and prior spontaneous preterm birth (17 to 33 + 6 weeks' gestation) were screened for a short cervix by serial transvaginal ultrasound evaluations between 16 and 22 + 6 weeks. Women with a short cervix (cervical length < 25 mm) were randomly assigned to cerclage or not. Linear and logistic regression were used to assess the relationship between BMI and continuous and categorical variables, respectively | ||
| 520 | |a RESULTS: Overall, in the screened women (n = 986), BMI was not associated with cervical length (P = 0.68), gestational age at delivery (P = 0.12) or birth at < 35 weeks (P = 0.68). For the cerclage group (n = 148), BMI had no significant effect. For the no-cerclage group (n = 153), BMI was associated with a decrease in gestational age at delivery, with an estimated slope of - 0.14 weeks per kg/m(2) (P = 0.03; including adjustment for cervical length). This result was driven primarily by several women with BMI > 47 kg/m(2) | ||
| 520 | |a CONCLUSION: In women at high risk for recurrent preterm birth, BMI was not associated with cervical length or gestational age at birth. BMI did not appear to adversely affect ultrasound-indicated cerclage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 700 | 1 | |a Wing, D A |e verfasserin |4 aut | |
| 700 | 1 | |a Szychowski, J M |e verfasserin |4 aut | |
| 700 | 1 | |a Owen, J |e verfasserin |4 aut | |
| 700 | 1 | |a Hankins, G |e verfasserin |4 aut | |
| 700 | 1 | |a Iams, J D |e verfasserin |4 aut | |
| 700 | 1 | |a Sheffield, J S |e verfasserin |4 aut | |
| 700 | 1 | |a Perez-Delboy, A |e verfasserin |4 aut | |
| 700 | 1 | |a Berghella, V |e verfasserin |4 aut | |
| 700 | 1 | |a Guzman, E R |e verfasserin |4 aut | |
| 700 | 0 | |a Vaginal Ultrasound Trial Consortium |e verfasserin |4 aut | |
| 700 | 1 | |a Ramin, Susan |e investigator |4 oth | |
| 700 | 1 | |a Tomlinson, Mark |e investigator |4 oth | |
| 700 | 1 | |a Knudtson, Eric |e investigator |4 oth | |
| 700 | 1 | |a Egerman, Robert |e investigator |4 oth | |
| 700 | 1 | |a Silver, Richard |e investigator |4 oth | |
| 700 | 1 | |a How, Helen |e investigator |4 oth | |
| 700 | 1 | |a Gordon, Mike |e investigator |4 oth | |
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