QuantiFERON-TB Gold In-Tube test for diagnosis of latent tuberculosis (TB) infection in solid organ transplant candidates : a single-center study in an area endemic for TB
© 2012 John Wiley & Sons A/S..
BACKGROUND: The prevalence of Mycobacterium tuberculosis in transplant recipients is estimated to be 50 times higher than in the general population, with a mortality rate of around 40%. Diagnosis and treatment of latent tuberculosis (TB) infection (LTBI) is an essential strategy for TB control. In this study we compared the QuantiFERON-TB Gold In-Tube test (QFT) with the tuberculin skin test (TST) for detection of LTBI in solid organ transplant (SOT) candidates.
PATIENTS AND METHODS: Between March 2008 and September 2011, 187 transplant candidates, who were referred to the transplant clinic of Imam-Khomeini Hospital, were enrolled in the study. Patients were screened for LTBI with both QFT and TST. Twenty-three patients (12.3%) were excluded for failure to follow up. Concordance between the 2 tests, and variables associated with test discordance were assessed.
RESULTS: The mean age of patients was 40 years (range: 11-65) and male-to-female ratio was 1.2 (88/76). TST and QFT were positive in 26 (15.9%) and 33 (20.1%) patients, respectively. Five cases (3.1%) had indeterminate QFT. Overall agreement between QFT and TST was about 80% (k = 0.32, P-value = 0.0001).
CONCLUSION: Considering the fair overall agreement between the 2 tests, and greater ease of the QFT from the patient's point of view, QFT is recommended for detection of LTBI in SOT candidates.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Transplant infectious disease : an official journal of the Transplantation Society - 15(2013), 1 vom: 13. Feb., Seite 90-5 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ahmadinejad, Z [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 15.08.2013 Date Revised 06.02.2013 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/tid.12027 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM222823488 |
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| 500 | |a Date Revised 06.02.2013 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2012 John Wiley & Sons A/S. | ||
| 520 | |a BACKGROUND: The prevalence of Mycobacterium tuberculosis in transplant recipients is estimated to be 50 times higher than in the general population, with a mortality rate of around 40%. Diagnosis and treatment of latent tuberculosis (TB) infection (LTBI) is an essential strategy for TB control. In this study we compared the QuantiFERON-TB Gold In-Tube test (QFT) with the tuberculin skin test (TST) for detection of LTBI in solid organ transplant (SOT) candidates | ||
| 520 | |a PATIENTS AND METHODS: Between March 2008 and September 2011, 187 transplant candidates, who were referred to the transplant clinic of Imam-Khomeini Hospital, were enrolled in the study. Patients were screened for LTBI with both QFT and TST. Twenty-three patients (12.3%) were excluded for failure to follow up. Concordance between the 2 tests, and variables associated with test discordance were assessed | ||
| 520 | |a RESULTS: The mean age of patients was 40 years (range: 11-65) and male-to-female ratio was 1.2 (88/76). TST and QFT were positive in 26 (15.9%) and 33 (20.1%) patients, respectively. Five cases (3.1%) had indeterminate QFT. Overall agreement between QFT and TST was about 80% (k = 0.32, P-value = 0.0001) | ||
| 520 | |a CONCLUSION: Considering the fair overall agreement between the 2 tests, and greater ease of the QFT from the patient's point of view, QFT is recommended for detection of LTBI in SOT candidates | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Azmoudeh Ardalan, F |e verfasserin |4 aut | |
| 700 | 1 | |a Razzaqi, M |e verfasserin |4 aut | |
| 700 | 1 | |a Davoudi, S |e verfasserin |4 aut | |
| 700 | 1 | |a Jafarian, A |e verfasserin |4 aut | |
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