Hepatitis C virus variants with decreased sensitivity to direct-acting antivirals (DAAs) were rarely observed in DAA-naive patients prior to treatment
The prevalence of naturally occurring hepatitis C virus (HCV) variants that are less sensitive to direct-acting antiviral (DAA) inhibitors has not been fully characterized. We used population sequence analysis to assess the frequency of such variants in plasma samples from 3,447 DAA-naive patients with genotype 1 HCV. In general, HCV variants with lower-level resistance (3- to 25-fold increased 50% inhibitor concentration [IC(50)]) to telaprevir were observed as the dominant species in 0 to 3% of patients, depending on the specific variant, whereas higher-level resistant variants (>25-fold-increased IC(50)) were not observed. Specific variants resistant to NS5A inhibitors were predominant in up to 6% of patients. Most variants resistant to nucleo(s/t)ide active-site NS5B polymerase inhibitors were not observed, whereas variants resistant to non-nucleoside allosteric inhibitors were observed in up to 18% of patients. The presence of DAA-resistant variants in NS5A, NS5B, or NS3 (including telaprevir-resistant variants), in baseline samples of treatment-naive patients receiving a telaprevir-based regimen in phase 3 studies did not affect the sustained viral response (SVR). Treatment-naive patients with viral populations containing the telaprevir-resistant variants NS3 V36M, T54S, or R155K at baseline achieved a 74% SVR rate, whereas patients with no resistant variants detected prior to treatment achieved a 76% SVR rate. The effect of specific resistant variant frequency on response to various DAA treatments in different patient populations, including interferon nonresponders, should be further studied.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2013 |
|---|---|
| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:87 |
|---|---|
| Enthalten in: |
Journal of virology - 87(2013), 3 vom: 04. Feb., Seite 1544-53 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Bartels, Doug J [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antiviral Agents |
|---|
| Anmerkungen: |
Date Completed 05.03.2013 Date Revised 17.03.2022 published: Print-Electronic GENBANK: KC123434, KC123435, KC123436, KC123437, KC123438, KC123439, KC123440, KC123441, KC123442, KC123443, KC123444, KC123445, KC123446, KC123447, KC123448, KC123449, KC123450, KC123451, KC123452, KC123453, KC123454, KC123455, KC123456, KC123457, KC123458, KC123459, KC123460, KC123461, KC123462, KC123463, KC123464, KC123465, KC123466, KC123467, KC123468, KC123469, KC123470, KC123471, KC123472, KC123473, KC123474, KC123475, KC123476, KC123477, KC123478, KC123479, KC123480, KC123481, KC123482, KC123483, KC123484, KC123485, KC123486, KC123487, KC123488, KC123489, KC123490, KC123491, KC123492, KC123493, KC123494, KC123495, KC123496, KC123497, KC123498, KC123499, KC123500, KC123501, KC123502, KC123503, KC123504, KC123505, KC123506, KC123507, KC123508, KC123509, KC123510, KC123511, KC123512, KC123513, KC123514, KC123515, KC123516, KC123517, KC123518, KC123519, KC123520, KC123521, KC123522, KC123523, KC123524, KC123525, KC123526, KC123527, KC123528, KC123529, KC123530, KC123531, KC123532, KC123533, KC123534, KC123535, KC123536, KC123537, KC123538, KC123539, KC123540, KC123541, KC123542, KC123543, KC123544, KC123545, KC123546, KC123547, KC123548, KC123549, KC123550, KC123551, KC123552, KC123553, KC123554, KC123555, KC123556, KC123557, KC123558, KC123559, KC123560, KC123561, KC123562, KC123563, KC123564, KC123565, KC123566, KC123567, KC123568, KC123569, KC123570, KC123571, KC123572, KC123573, KC123574, KC123575, KC123576, KC123577, KC123578, KC123579, KC123580, KC123581, KC123582, KC123583, KC123584, KC123585, KC123586, KC123587, KC123588, KC123589, KC123590, KC123591, KC123592, KC123593, KC123594, KC123595, KC123596, KC123597, KC123598, KC123599, KC123600, KC123601, KC123602, KC123603, KC123604, KC123605, KC123606, KC123607, KC123608, KC123609, KC123610, KC123611, KC123612, KC123613, KC123614, KC123615, KC123616, KC123617, KC123618, KC123619, KC123620, KC123621, KC123622, KC123623, KC123624, KC123625, KC123626, KC123627, KC123628, KC123629, KC123630, KC123631, KC123632, KC123633, KC123634, KC123635, KC123636, KC123637, KC123638, KC123639, KC123640, KC123641, KC123642, KC123643, KC123644, KC123645, KC123646, KC123647, KC123648, KC123649, KC123650, KC123651, KC123652, KC123653, KC123654, KC123655, KC123656, KC123657, KC123658, KC123659, KC123660, KC123661, KC123662, KC123663, KC123664, KC123665, KC123666, KC123667, KC123668, KC123669, KC123670, KC123671, KC123672, KC123673, KC123674, KC123675, KC123676, KC123677, KC123678, KC123679, KC123680, KC123681, KC123682, KC123683, KC123684, KC123685, KC123686, KC123687, KC123688, KC123689, KC123690, KC123691, KC123692, KC123693, KC123694, KC123695, KC123696, KC123697, KC123698, KC123699, KC123700, KC123701, KC123702, KC123703, KC123704, KC123705, KC123706, KC123707, KC123708, KC123709, KC123710, KC123711, KC123712, KC123713, KC123714, KC123715, KC123716, KC123717, KC123718, KC123719, KC123720, KC123721, KC123722, KC123723, KC123724, KC123725, KC123726, KC123727, KC123728, KC123729, KC123730, KC123731, KC123732, KC123733, KC123734, KC123735, KC123736, KC123737, KC123738, KC123739, KC123740, KC123741, KC123742, KC123743, KC123744, KC123745, KC123746, KC123747, KC123748, KC123749, KC123750, KC123751, KC123752, KC123753, KC123754, KC123755, KC123756, KC123757, KC123758, KC123759, KC123760, KC123761, KC123762, KC123763, KC123764, KC123765, KC123766, KC123767, KC123768, KC123769, KC123770, KC123771, KC123772, KC123773, KC123774, KC123775, KC123776, KC123777, KC123778, KC123779, KC123780, KC123781, KC123782, KC123783, KC123784, KC123785, KC123786, KC123787, KC123788, KC123789, KC123790, KC123791, KC123792, KC123793, KC123794, KC123795, KC123796, KC123797, KC123798, KC123799, KC123800, KC123801, KC123802, KC123803, KC123804, KC123805, KC123806, KC123807, KC123808, KC123809, KC123810, KC123811, KC123812, KC123813, KC123814, KC123815, KC123816, KC123817, KC123818, KC123819, KC123820, KC123821, KC123822, KC123823, KC123824, KC123825, KC123826, KC123827, KC123828, KC123829, KC123830, KC123831, KC123832, KC123833, KC123834, KC123835, KC123836, KC123837, KC123838, KC123839, KC123840, KC123841, KC123842, KC123843, KC123844, KC123845, KC123846, KC123847, KC123848, KC123849, KC123850, KC123851, KC123852, KC123853, KC123854, KC123855, KC123856, KC123857, KC123858, KC123859, KC123860, KC123861, KC123862, KC123863, KC123864, KC123865, KC123866, KC123867, KC123868, KC123869, KC123870, KC123871, KC123872, KC123873, KC123874, KC123875, KC123876, KC123877, KC123878, KC123879, KC123880, KC123881, KC123882, KC123883, KC123884, KC123885, KC123886, KC123887, KC123888, KC123889, KC123890, KC123891, KC123892, KC123893, KC123894, KC123895, KC123896, KC123897, KC123898, KC123899, KC123900, KC123901, KC123902, KC123903, KC123904, KC123905, KC123906, KC123907, KC123908, KC123909, KC123910, KC123911, KC123912, KC123913, KC123914, KC123915, KC123916, KC123917, KC123918, KC123919, KC123920, KC123921, KC123922, KC123923, KC123924, KC123925, KC123926, KC123927, KC123928, KC123929, KC123930, KC123931, KC123932, KC123933, KC123934, KC123935, KC123936, KC123937, KC123938, KC123939, KC123940, KC123941, KC123942, KC123943, KC123944, KC123945, KC123946, KC123947, KC123948, KC123949, KC123950, KC123951, KC123952, KC123953, KC123954, KC123955, KC123956, KC123957, KC123958, KC123959, KC123960, KC123961, KC123962, KC123963, KC123964, KC123965, KC123966, KC123967, KC123968, KC123969, KC123970, KC123971, KC123972, KC123973, KC123974, KC123975, KC123976, KC123977, KC123978, KC123979, KC123980, KC123981, KC123982, KC123983, KC123984, KC123985, KC123986, KC123987, KC123988, KC123989, KC123990, KC123991, KC123992, KC123993, KC123994, KC123995, KC123996, KC123997, KC123998, KC123999, KC124000, KC124001, KC124002, KC124003, KC124004, KC124005, KC124006, KC124007, KC124008, KC124009, KC124010, KC124011, KC124012, KC124013, KC124014, KC124015, KC124016, KC124017, KC124018, KC124019, KC124020, KC124021, KC124022, KC124023, KC124024, KC124025, KC124026, KC124027, KC124028, KC124029, KC124030, KC124031, KC124032, KC124033, KC124034, KC124035, KC124036, KC124037, KC124038, KC124039, KC124040, KC124041, KC124042, KC124043, KC124044, KC124045, KC124046, KC124047, KC124048, KC124049, KC124050, KC124051, KC124052, KC124053, KC124054, KC124055, KC124056, KC124057, KC124058, KC124059, KC124060, KC124061, KC124062, KC124063, KC124064, KC124065, KC124066, KC124067, KC124068, KC124069, KC124070, KC124071, KC124072, KC124073, KC124074, KC124075, KC124076, KC124077, KC124078, KC124079, KC124080, KC124081, KC124082, KC124083, KC124084, KC124085, KC124086, KC124087, KC124088, KC124089, KC124090, KC124091, KC124092, KC124093, KC124094, KC124095, KC124096, KC124097, KC124098, KC124099, KC124100, KC124101, KC124102, KC124103, KC124104, KC124105, KC124106, KC124107, KC124108, KC124109, KC124110, KC124111, KC124112, KC124113, KC124114, KC124115, KC124116, KC124117, KC124118, KC124119, KC124120, KC124121, KC124122, KC124123, KC124124, KC124125, KC124126, KC124127, KC124128, KC124129, KC124130, KC124131, KC124132, KC124133, KC124134, KC124135, KC124136, KC124137, KC124138, KC124139, KC124140, KC124141, KC124142, KC124143, KC124144, KC124145, KC124146, KC124147, KC124148, KC124149, KC124150, KC124151, KC124152, KC124153, KC124154, KC124155, KC124156, KC124157, KC124158, KC124159, KC124160, KC124161, KC124162, KC124163, KC124164, KC124165, KC124166, KC124167, KC124168, KC124169, KC124170, KC124171, KC124172, KC124173, KC124174, KC124175, KC124176, KC124177, KC124178, KC124179, KC124180, KC124181, KC124182, KC124183, KC124184, KC124185, KC124186, KC124187, KC124188, KC124189, KC124190, KC124191, KC124192, KC124193, KC124194, KC124195, KC124196, KC124197, KC124198, KC124199, KC124200, KC124201, KC124202, KC124203, KC124204, KC124205, KC124206, KC124207, KC124208, KC124209, KC124210, KC124211, KC124212, KC124213, KC124214, KC124215, KC124216, KC124217, KC124218, KC124219, KC124220, KC124221, KC124222, KC124223, KC124224, KC124225, KC124226, KC124227, KC124228, KC124229, KC124230, KC124231, KC124232, KC124233, KC124234, KC124235, KC124236, KC124237, KC124238, KC124239, KC124240, KC124241, KC124242, KC124243, KC124244, KC124245, KC124246, KC124247, KC124248, KC124249, KC124250, KC124251, KC124252, KC124253, KC124254, KC124255, KC124256, KC124257, KC124258, KC124259, KC124260, KC124261, KC124262, KC124263, KC124264, KC124265, KC124266, KC124267, KC124268, KC124269, KC124270, KC124271, KC124272, KC124273, KC124274, KC124275, KC124276, KC124277, KC124278, KC124279, KC124280, KC124281, KC124282, KC124283, KC124284, KC124285, KC124286, KC124287, KC124288, KC124289, KC124290, KC124291, KC124292, KC124293, KC124294, KC124295, KC124296, KC124297, KC124298, KC124299, KC124300, KC124301, KC124302, KC124303, KC124304, KC124305, KC124306, KC124307, KC124308, KC124309, KC124310, KC124311, KC124312, KC124313, KC124314, KC124315, KC124316, KC124317, KC124318, KC124319, KC124320, KC124321, KC124322, KC124323, KC124324, KC124325, KC124326, KC124327, KC124328, KC124329, KC124330, KC124331, KC124332, K... Citation Status MEDLINE |
|---|
| doi: |
10.1128/JVI.02294-12 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM222625872 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM222625872 | ||
| 003 | DE-627 | ||
| 005 | 20231224054714.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1128/JVI.02294-12 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0742.xml |
| 035 | |a (DE-627)NLM222625872 | ||
| 035 | |a (NLM)23152524 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Bartels, Doug J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hepatitis C virus variants with decreased sensitivity to direct-acting antivirals (DAAs) were rarely observed in DAA-naive patients prior to treatment |
| 264 | 1 | |c 2013 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.03.2013 | ||
| 500 | |a Date Revised 17.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a GENBANK: KC123434, KC123435, KC123436, KC123437, KC123438, KC123439, KC123440, KC123441, KC123442, KC123443, KC123444, KC123445, KC123446, KC123447, KC123448, KC123449, KC123450, KC123451, KC123452, KC123453, KC123454, KC123455, KC123456, KC123457, KC123458, KC123459, KC123460, KC123461, KC123462, KC123463, KC123464, KC123465, KC123466, KC123467, KC123468, KC123469, KC123470, KC123471, KC123472, KC123473, KC123474, KC123475, KC123476, KC123477, KC123478, KC123479, KC123480, KC123481, KC123482, KC123483, KC123484, KC123485, KC123486, KC123487, KC123488, KC123489, KC123490, KC123491, KC123492, KC123493, KC123494, KC123495, KC123496, KC123497, KC123498, KC123499, KC123500, KC123501, KC123502, KC123503, KC123504, KC123505, KC123506, KC123507, KC123508, KC123509, KC123510, KC123511, KC123512, KC123513, KC123514, KC123515, KC123516, KC123517, KC123518, KC123519, KC123520, KC123521, KC123522, KC123523, KC123524, KC123525, KC123526, KC123527, KC123528, KC123529, KC123530, KC123531, KC123532, KC123533, KC123534, KC123535, KC123536, KC123537, KC123538, KC123539, KC123540, KC123541, KC123542, KC123543, KC123544, KC123545, KC123546, KC123547, KC123548, KC123549, KC123550, KC123551, KC123552, KC123553, KC123554, KC123555, KC123556, KC123557, KC123558, KC123559, KC123560, KC123561, KC123562, KC123563, KC123564, KC123565, KC123566, KC123567, KC123568, KC123569, KC123570, KC123571, KC123572, KC123573, KC123574, KC123575, KC123576, KC123577, KC123578, KC123579, KC123580, KC123581, KC123582, KC123583, KC123584, KC123585, KC123586, KC123587, KC123588, KC123589, KC123590, KC123591, KC123592, KC123593, KC123594, KC123595, KC123596, KC123597, KC123598, KC123599, KC123600, KC123601, KC123602, KC123603, KC123604, KC123605, KC123606, KC123607, KC123608, KC123609, KC123610, KC123611, KC123612, KC123613, KC123614, KC123615, KC123616, KC123617, KC123618, KC123619, KC123620, KC123621, KC123622, KC123623, KC123624, KC123625, KC123626, KC123627, KC123628, KC123629, KC123630, KC123631, KC123632, KC123633, KC123634, KC123635, KC123636, KC123637, KC123638, KC123639, KC123640, KC123641, KC123642, KC123643, KC123644, KC123645, KC123646, KC123647, KC123648, KC123649, KC123650, KC123651, KC123652, KC123653, KC123654, KC123655, KC123656, KC123657, KC123658, KC123659, KC123660, KC123661, KC123662, KC123663, KC123664, KC123665, KC123666, KC123667, KC123668, KC123669, KC123670, KC123671, KC123672, KC123673, KC123674, KC123675, KC123676, KC123677, KC123678, KC123679, KC123680, KC123681, KC123682, KC123683, KC123684, KC123685, KC123686, KC123687, KC123688, KC123689, KC123690, KC123691, KC123692, KC123693, KC123694, KC123695, KC123696, KC123697, KC123698, KC123699, KC123700, KC123701, KC123702, KC123703, KC123704, KC123705, KC123706, KC123707, KC123708, KC123709, KC123710, KC123711, KC123712, KC123713, KC123714, KC123715, KC123716, KC123717, KC123718, KC123719, KC123720, KC123721, KC123722, KC123723, KC123724, KC123725, KC123726, KC123727, KC123728, KC123729, KC123730, KC123731, KC123732, KC123733, KC123734, KC123735, KC123736, KC123737, KC123738, KC123739, KC123740, KC123741, KC123742, KC123743, KC123744, KC123745, KC123746, KC123747, KC123748, KC123749, KC123750, KC123751, KC123752, KC123753, KC123754, KC123755, KC123756, KC123757, KC123758, KC123759, KC123760, KC123761, KC123762, KC123763, KC123764, KC123765, KC123766, KC123767, KC123768, KC123769, KC123770, KC123771, KC123772, KC123773, KC123774, KC123775, KC123776, KC123777, KC123778, KC123779, KC123780, KC123781, KC123782, KC123783, KC123784, KC123785, KC123786, KC123787, KC123788, KC123789, KC123790, KC123791, KC123792, KC123793, KC123794, KC123795, KC123796, KC123797, KC123798, KC123799, KC123800, KC123801, KC123802, KC123803, KC123804, KC123805, KC123806, KC123807, KC123808, KC123809, KC123810, KC123811, KC123812, KC123813, KC123814, KC123815, KC123816, KC123817, KC123818, KC123819, KC123820, KC123821, KC123822, KC123823, KC123824, KC123825, KC123826, KC123827, KC123828, KC123829, KC123830, KC123831, KC123832, KC123833, KC123834, KC123835, KC123836, KC123837, KC123838, KC123839, KC123840, KC123841, KC123842, KC123843, KC123844, KC123845, KC123846, KC123847, KC123848, KC123849, KC123850, KC123851, KC123852, KC123853, KC123854, KC123855, KC123856, KC123857, KC123858, KC123859, KC123860, KC123861, KC123862, KC123863, KC123864, KC123865, KC123866, KC123867, KC123868, KC123869, KC123870, KC123871, KC123872, KC123873, KC123874, KC123875, KC123876, KC123877, KC123878, KC123879, KC123880, KC123881, KC123882, KC123883, KC123884, KC123885, KC123886, KC123887, KC123888, KC123889, KC123890, KC123891, KC123892, KC123893, KC123894, KC123895, KC123896, KC123897, KC123898, KC123899, KC123900, KC123901, KC123902, KC123903, KC123904, KC123905, KC123906, KC123907, KC123908, KC123909, KC123910, KC123911, KC123912, KC123913, KC123914, KC123915, KC123916, KC123917, KC123918, KC123919, KC123920, KC123921, KC123922, KC123923, KC123924, KC123925, KC123926, KC123927, KC123928, KC123929, KC123930, KC123931, KC123932, KC123933, KC123934, KC123935, KC123936, KC123937, KC123938, KC123939, KC123940, KC123941, KC123942, KC123943, KC123944, KC123945, KC123946, KC123947, KC123948, KC123949, KC123950, KC123951, KC123952, KC123953, KC123954, KC123955, KC123956, KC123957, KC123958, KC123959, KC123960, KC123961, KC123962, KC123963, KC123964, KC123965, KC123966, KC123967, KC123968, KC123969, KC123970, KC123971, KC123972, KC123973, KC123974, KC123975, KC123976, KC123977, KC123978, KC123979, KC123980, KC123981, KC123982, KC123983, KC123984, KC123985, KC123986, KC123987, KC123988, KC123989, KC123990, KC123991, KC123992, KC123993, KC123994, KC123995, KC123996, KC123997, KC123998, KC123999, KC124000, KC124001, KC124002, KC124003, KC124004, KC124005, KC124006, KC124007, KC124008, KC124009, KC124010, KC124011, KC124012, KC124013, KC124014, KC124015, KC124016, KC124017, KC124018, KC124019, KC124020, KC124021, KC124022, KC124023, KC124024, KC124025, KC124026, KC124027, KC124028, KC124029, KC124030, KC124031, KC124032, KC124033, KC124034, KC124035, KC124036, KC124037, KC124038, KC124039, KC124040, KC124041, KC124042, KC124043, KC124044, KC124045, KC124046, KC124047, KC124048, KC124049, KC124050, KC124051, KC124052, KC124053, KC124054, KC124055, KC124056, KC124057, KC124058, KC124059, KC124060, KC124061, KC124062, KC124063, KC124064, KC124065, KC124066, KC124067, KC124068, KC124069, KC124070, KC124071, KC124072, KC124073, KC124074, KC124075, KC124076, KC124077, KC124078, KC124079, KC124080, KC124081, KC124082, KC124083, KC124084, KC124085, KC124086, KC124087, KC124088, KC124089, KC124090, KC124091, KC124092, KC124093, KC124094, KC124095, KC124096, KC124097, KC124098, KC124099, KC124100, KC124101, KC124102, KC124103, KC124104, KC124105, KC124106, KC124107, KC124108, KC124109, KC124110, KC124111, KC124112, KC124113, KC124114, KC124115, KC124116, KC124117, KC124118, KC124119, KC124120, KC124121, KC124122, KC124123, KC124124, KC124125, KC124126, KC124127, KC124128, KC124129, KC124130, KC124131, KC124132, KC124133, KC124134, KC124135, KC124136, KC124137, KC124138, KC124139, KC124140, KC124141, KC124142, KC124143, KC124144, KC124145, KC124146, KC124147, KC124148, KC124149, KC124150, KC124151, KC124152, KC124153, KC124154, KC124155, KC124156, KC124157, KC124158, KC124159, KC124160, KC124161, KC124162, KC124163, KC124164, KC124165, KC124166, KC124167, KC124168, KC124169, KC124170, KC124171, KC124172, KC124173, KC124174, KC124175, KC124176, KC124177, KC124178, KC124179, KC124180, KC124181, KC124182, KC124183, KC124184, KC124185, KC124186, KC124187, KC124188, KC124189, KC124190, KC124191, KC124192, KC124193, KC124194, KC124195, KC124196, KC124197, KC124198, KC124199, KC124200, KC124201, KC124202, KC124203, KC124204, KC124205, KC124206, KC124207, KC124208, KC124209, KC124210, KC124211, KC124212, KC124213, KC124214, KC124215, KC124216, KC124217, KC124218, KC124219, KC124220, KC124221, KC124222, KC124223, KC124224, KC124225, KC124226, KC124227, KC124228, KC124229, KC124230, KC124231, KC124232, KC124233, KC124234, KC124235, KC124236, KC124237, KC124238, KC124239, KC124240, KC124241, KC124242, KC124243, KC124244, KC124245, KC124246, KC124247, KC124248, KC124249, KC124250, KC124251, KC124252, KC124253, KC124254, KC124255, KC124256, KC124257, KC124258, KC124259, KC124260, KC124261, KC124262, KC124263, KC124264, KC124265, KC124266, KC124267, KC124268, KC124269, KC124270, KC124271, KC124272, KC124273, KC124274, KC124275, KC124276, KC124277, KC124278, KC124279, KC124280, KC124281, KC124282, KC124283, KC124284, KC124285, KC124286, KC124287, KC124288, KC124289, KC124290, KC124291, KC124292, KC124293, KC124294, KC124295, KC124296, KC124297, KC124298, KC124299, KC124300, KC124301, KC124302, KC124303, KC124304, KC124305, KC124306, KC124307, KC124308, KC124309, KC124310, KC124311, KC124312, KC124313, KC124314, KC124315, KC124316, KC124317, KC124318, KC124319, KC124320, KC124321, KC124322, KC124323, KC124324, KC124325, KC124326, KC124327, KC124328, KC124329, KC124330, KC124331, KC124332, K... | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The prevalence of naturally occurring hepatitis C virus (HCV) variants that are less sensitive to direct-acting antiviral (DAA) inhibitors has not been fully characterized. We used population sequence analysis to assess the frequency of such variants in plasma samples from 3,447 DAA-naive patients with genotype 1 HCV. In general, HCV variants with lower-level resistance (3- to 25-fold increased 50% inhibitor concentration [IC(50)]) to telaprevir were observed as the dominant species in 0 to 3% of patients, depending on the specific variant, whereas higher-level resistant variants (>25-fold-increased IC(50)) were not observed. Specific variants resistant to NS5A inhibitors were predominant in up to 6% of patients. Most variants resistant to nucleo(s/t)ide active-site NS5B polymerase inhibitors were not observed, whereas variants resistant to non-nucleoside allosteric inhibitors were observed in up to 18% of patients. The presence of DAA-resistant variants in NS5A, NS5B, or NS3 (including telaprevir-resistant variants), in baseline samples of treatment-naive patients receiving a telaprevir-based regimen in phase 3 studies did not affect the sustained viral response (SVR). Treatment-naive patients with viral populations containing the telaprevir-resistant variants NS3 V36M, T54S, or R155K at baseline achieved a 74% SVR rate, whereas patients with no resistant variants detected prior to treatment achieved a 76% SVR rate. The effect of specific resistant variant frequency on response to various DAA treatments in different patient populations, including interferon nonresponders, should be further studied | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 650 | 7 | |a NS3 protein, hepatitis C virus |2 NLM | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 650 | 7 | |a Viral Nonstructural Proteins |2 NLM | |
| 650 | 7 | |a NS-5 protein, hepatitis C virus |2 NLM | |
| 650 | 7 | |a EC 2.7.7.48 |2 NLM | |
| 700 | 1 | |a Sullivan, James C |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Eileen Z |e verfasserin |4 aut | |
| 700 | 1 | |a Tigges, Ann M |e verfasserin |4 aut | |
| 700 | 1 | |a Dorrian, Jennifer L |e verfasserin |4 aut | |
| 700 | 1 | |a De Meyer, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Takemoto, Darin |e verfasserin |4 aut | |
| 700 | 1 | |a Dondero, Elizabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Kwong, Ann D |e verfasserin |4 aut | |
| 700 | 1 | |a Picchio, Gaston |e verfasserin |4 aut | |
| 700 | 1 | |a Kieffer, Tara L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of virology |d 1967 |g 87(2013), 3 vom: 04. Feb., Seite 1544-53 |w (DE-627)NLM000006866 |x 1098-5514 |7 nnns |
| 773 | 1 | 8 | |g volume:87 |g year:2013 |g number:3 |g day:04 |g month:02 |g pages:1544-53 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1128/JVI.02294-12 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 87 |j 2013 |e 3 |b 04 |c 02 |h 1544-53 | ||