Anti-HCV testing as a basic standard of monitoring HCV mother-to-child infection : advantages and disadvantages of the method
UNLABELLED: Vertical transmission is an important route of HCV infection. Infants are considered to be infected if two or more HCV-RNA results are positive and/or anti-HCV+ over 18 mo of age. HCV-RNA RT-PCR testing requires high quality certificated centers. Anti-HCV ELISA commercial tests are cheaper and may be performed in all laboratories.
AIM: To estimate sufficiency of anti-HCV testing over 18 mo in the diagnostic process of HCV mother-to-child infection.
METHODS: 317 children born to HCV infected mothers were observed for 2-4 years. HCV-RNA was determined first at the age of 2-5 mo and subsequent in 6 months intervals, anti-HCV every 3-6 months.
RESULTS: HCV infection (HCV-RNA twice presence) was recognized in 26/317 (8.2%). Anti-HCV+ were found in: 288 (91%) children in 3-6 mo of age, 213 (67.2%) in 7-9 mo, 21 (6.6%) above 18 mo. HCV-RNA was negative during all observation in the group with anti-HCV results group in all determinations in the first year of life. Among 21 children anti-HCV+ over 18 mo there were: 18 with chronic infection (HCV-RNA+, anti-HCV+), 3 achieved HCV-RNA clearance (2 became anti-HCV-, 1 anti-HCV+ during following observation). Among 296 children anti-HCV over 18 mo there were 5 children HCV-RNA+ twice in the first year of life, but all became HCV-RNA- during follow up. In 4 of them (4/296, 1.3%) in spite of anti-HCV- we transiently found HCV-RNA+ above 18 mo of age.
CONCLUSIONS: Anti-HCV presence in children born to HCV infected mothers: a) up to 18 mo of age do not confirm HCV infection. b) over 18 mo of age are indicative of HCV infection, but not always with active HCV replication. Negative results of anti-HCV above 18 mo of age usually allow us to exclude HCV replication, but in 1.3% we found HCV-RNA in anti-HCV- children. Anti-HCV testing over 18 mo of age as only diagnostic procedure may be not enough. Missing HCV replication in the first period of life prevents HCV microreplication follow up.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
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| Enthalten in: |
Przeglad epidemiologiczny - 66(2012), 2 vom: 24., Seite 341-5 |
| Sprache: |
Polnisch |
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| Weiterer Titel: |
Badanie przeciwciał anty-HCV jako podstawowy standard monitorowania zakazenia odmatczynego HCV: zalety i wady metody |
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| Beteiligte Personen: |
Aniszewska, Małgorzata [VerfasserIn] |
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| Themen: |
English Abstract |
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| Anmerkungen: |
Date Completed 19.11.2012 Date Revised 29.10.2012 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM222135778 |
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| 100 | 1 | |a Aniszewska, Małgorzata |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Anti-HCV testing as a basic standard of monitoring HCV mother-to-child infection |b advantages and disadvantages of the method |
| 246 | 3 | 3 | |a Badanie przeciwciał anty-HCV jako podstawowy standard monitorowania zakazenia odmatczynego HCV: zalety i wady metody |
| 264 | 1 | |c 2012 | |
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| 500 | |a Date Completed 19.11.2012 | ||
| 500 | |a Date Revised 29.10.2012 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a UNLABELLED: Vertical transmission is an important route of HCV infection. Infants are considered to be infected if two or more HCV-RNA results are positive and/or anti-HCV+ over 18 mo of age. HCV-RNA RT-PCR testing requires high quality certificated centers. Anti-HCV ELISA commercial tests are cheaper and may be performed in all laboratories | ||
| 520 | |a AIM: To estimate sufficiency of anti-HCV testing over 18 mo in the diagnostic process of HCV mother-to-child infection | ||
| 520 | |a METHODS: 317 children born to HCV infected mothers were observed for 2-4 years. HCV-RNA was determined first at the age of 2-5 mo and subsequent in 6 months intervals, anti-HCV every 3-6 months | ||
| 520 | |a RESULTS: HCV infection (HCV-RNA twice presence) was recognized in 26/317 (8.2%). Anti-HCV+ were found in: 288 (91%) children in 3-6 mo of age, 213 (67.2%) in 7-9 mo, 21 (6.6%) above 18 mo. HCV-RNA was negative during all observation in the group with anti-HCV results group in all determinations in the first year of life. Among 21 children anti-HCV+ over 18 mo there were: 18 with chronic infection (HCV-RNA+, anti-HCV+), 3 achieved HCV-RNA clearance (2 became anti-HCV-, 1 anti-HCV+ during following observation). Among 296 children anti-HCV over 18 mo there were 5 children HCV-RNA+ twice in the first year of life, but all became HCV-RNA- during follow up. In 4 of them (4/296, 1.3%) in spite of anti-HCV- we transiently found HCV-RNA+ above 18 mo of age | ||
| 520 | |a CONCLUSIONS: Anti-HCV presence in children born to HCV infected mothers: a) up to 18 mo of age do not confirm HCV infection. b) over 18 mo of age are indicative of HCV infection, but not always with active HCV replication. Negative results of anti-HCV above 18 mo of age usually allow us to exclude HCV replication, but in 1.3% we found HCV-RNA in anti-HCV- children. Anti-HCV testing over 18 mo of age as only diagnostic procedure may be not enough. Missing HCV replication in the first period of life prevents HCV microreplication follow up | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Pokorska-Spiewak, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Marczyńska, Magdalena |e verfasserin |4 aut | |
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