Synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine via sequential radical processes
An efficient synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine is described (6 steps and 50% overall yield). The two phosphorus-carbon bonds in the perifosine analogue were prepared by sequential double radical hydrophosphinylation processes. This is the first example of a phosphinate analogue of perifosine, designed to be resistant to hydrolysis by phospholipid-metabolizing enzymes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Organic & biomolecular chemistry - 11(2013), 1 vom: 07. Jan., Seite 119-29 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Markoulides, Marios S [VerfasserIn] |
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| Links: |
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| Themen: |
107-73-3 |
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| Anmerkungen: |
Date Completed 16.05.2013 Date Revised 03.12.2012 published: Print Citation Status MEDLINE |
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| doi: |
10.1039/c2ob26395e |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM221885323 |
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| 520 | |a An efficient synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine is described (6 steps and 50% overall yield). The two phosphorus-carbon bonds in the perifosine analogue were prepared by sequential double radical hydrophosphinylation processes. This is the first example of a phosphinate analogue of perifosine, designed to be resistant to hydrolysis by phospholipid-metabolizing enzymes | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Free Radicals |2 NLM | |
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