Tinospinosides D, E, and tinospin E, further clerodane diterpenoids from Tinospora sagittata
Chemical investigation on the roots of Tinospora sagittata resulted in the isolation of three novel cis-clerodane diterpenoids, tinospinosides D, E, and tinospin E, together with two known compounds, columbin and columbin glucoside, and their structures were determined by extensive spectroscopic analyses, chemical reactions and computer-assisted calculations. The inhibitory activity of the isolated compounds and their chemical derivatives on nitric oxide production in lipopolysaccharide and interferon-γ activited J774.1 macrophage-like cells was also evaluated.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Chemical & pharmaceutical bulletin - 60(2012), 10 vom: 15., Seite 1324-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Huang, Chao [VerfasserIn] |
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| Themen: |
31C4KY9ESH |
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| Anmerkungen: |
Date Completed 06.03.2013 Date Revised 06.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM221568557 |
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| 520 | |a Chemical investigation on the roots of Tinospora sagittata resulted in the isolation of three novel cis-clerodane diterpenoids, tinospinosides D, E, and tinospin E, together with two known compounds, columbin and columbin glucoside, and their structures were determined by extensive spectroscopic analyses, chemical reactions and computer-assisted calculations. The inhibitory activity of the isolated compounds and their chemical derivatives on nitric oxide production in lipopolysaccharide and interferon-γ activited J774.1 macrophage-like cells was also evaluated | ||
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| 700 | 1 | |a Asada, Yoshihisa |e verfasserin |4 aut | |
| 700 | 1 | |a Koike, Kazuo |e verfasserin |4 aut | |
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