Debilitating progressive encephalitis in a patient with BTK deficiency
X-linked agammaglobulinemia (XLA), also known as Bruton's tyrosine kinase (BTK) deficiency, is a primary antibody deficiency, characterized by low number of B cells, agammaglobulinemia and increased susceptibility to a variety of infections. Herein, we report a case of XLA with confirmed BTK mutation that developed neurological deficits. While we could not detect any responsible microorganism in spite of comprehensive workup, brain magnetic resonance imaging revealed moderate brain atrophy. The diagnosis of progressive encephalitis was made for this patient. Patients with XLA have a higher chance of encephalitis compared with other primary antibody deficiencies. Given the violent nature of encephalitis, it is a concern among XLA patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
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| Enthalten in: |
Acta microbiologica et immunologica Hungarica - 59(2012), 3 vom: 12. Sept., Seite 335-42 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mohammadzadeh, Iraj [VerfasserIn] |
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| Links: |
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| Themen: |
Agammaglobulinaemia Tyrosine Kinase |
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| Anmerkungen: |
Date Completed 04.12.2012 Date Revised 01.12.2018 published: Print Citation Status MEDLINE |
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| doi: |
10.1556/AMicr.59.2012.3.4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM221066098 |
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| 245 | 1 | 0 | |a Debilitating progressive encephalitis in a patient with BTK deficiency |
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| 520 | |a X-linked agammaglobulinemia (XLA), also known as Bruton's tyrosine kinase (BTK) deficiency, is a primary antibody deficiency, characterized by low number of B cells, agammaglobulinemia and increased susceptibility to a variety of infections. Herein, we report a case of XLA with confirmed BTK mutation that developed neurological deficits. While we could not detect any responsible microorganism in spite of comprehensive workup, brain magnetic resonance imaging revealed moderate brain atrophy. The diagnosis of progressive encephalitis was made for this patient. Patients with XLA have a higher chance of encephalitis compared with other primary antibody deficiencies. Given the violent nature of encephalitis, it is a concern among XLA patients | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Khaledi, Mojdeh |e verfasserin |4 aut | |
| 700 | 1 | |a Salehiomran, Mohammad Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Aghamohammadi, Asghar |e verfasserin |4 aut | |
| 700 | 1 | |a Rezaei, Nima |e verfasserin |4 aut | |
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