Are systemic voriconazole and caspofungin ototoxic? An experimental study with rats
OBJECTIVES: To determine whether systemic administration of voriconazole and caspofungin causes ototoxicity.
METHODS: This study was conducted on 32 healthy male Wistar albino rats. The baseline auditory brainstem response (ABR) thresholds of all animals were obtained under general anesthesia. Then, the rats were randomly divided into 4 groups (groups I-IV), each group consisting of 8 rats. Rats in group I were injected intraperitoneally with voriconazole 10 mg/kg/day for 7 days, and the rats in the group II were injected intraperitoneally with caspofungin 5 mg/kg/day for 7 days. Group III received 120 mg/kg/day gentamicin for 7 days. Group IV received saline for 7 days. The animals were then observed for 7 days, and on 14th day of the trial, posttreatment ABRs of both ears were recorded.
RESULTS: We did not find any significant differences between pretreatment and posttreatment median ABR thresholds in the voriconazole, caspofungin, or saline groups. In the gentamicin group, there was a statistically significant difference between pretreatment and posttreatment ABR thresholds.
CONCLUSION: Caspofungin and voriconazole did not change ABR thresholds in speech frequencies after a 7-day-period of their administration. We believe that further animal studies must be performed after administration of these agents for a longer time period, and these findings must be consolidated with histopathological investigations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
|---|---|
| Enthalten in: |
Clinical and experimental otorhinolaryngology - 5(2012), 3 vom: 07. Sept., Seite 145-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Aydın, Emine [VerfasserIn] |
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| Links: |
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| Themen: |
Auditory brainstem responses |
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| Anmerkungen: |
Date Completed 17.09.2012 Date Revised 21.10.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3342/ceo.2012.5.3.145 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM221026959 |
|---|
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| 245 | 1 | 0 | |a Are systemic voriconazole and caspofungin ototoxic? An experimental study with rats |
| 264 | 1 | |c 2012 | |
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| 500 | |a Date Completed 17.09.2012 | ||
| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a OBJECTIVES: To determine whether systemic administration of voriconazole and caspofungin causes ototoxicity | ||
| 520 | |a METHODS: This study was conducted on 32 healthy male Wistar albino rats. The baseline auditory brainstem response (ABR) thresholds of all animals were obtained under general anesthesia. Then, the rats were randomly divided into 4 groups (groups I-IV), each group consisting of 8 rats. Rats in group I were injected intraperitoneally with voriconazole 10 mg/kg/day for 7 days, and the rats in the group II were injected intraperitoneally with caspofungin 5 mg/kg/day for 7 days. Group III received 120 mg/kg/day gentamicin for 7 days. Group IV received saline for 7 days. The animals were then observed for 7 days, and on 14th day of the trial, posttreatment ABRs of both ears were recorded | ||
| 520 | |a RESULTS: We did not find any significant differences between pretreatment and posttreatment median ABR thresholds in the voriconazole, caspofungin, or saline groups. In the gentamicin group, there was a statistically significant difference between pretreatment and posttreatment ABR thresholds | ||
| 520 | |a CONCLUSION: Caspofungin and voriconazole did not change ABR thresholds in speech frequencies after a 7-day-period of their administration. We believe that further animal studies must be performed after administration of these agents for a longer time period, and these findings must be consolidated with histopathological investigations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Auditory brainstem responses | |
| 650 | 4 | |a Caspofungin | |
| 650 | 4 | |a Otology | |
| 650 | 4 | |a Ototoxicity | |
| 650 | 4 | |a Voriconazole | |
| 700 | 1 | |a Aydoğan, Filiz |e verfasserin |4 aut | |
| 700 | 1 | |a Taştan, Eren |e verfasserin |4 aut | |
| 700 | 1 | |a Iriz, Ayşe |e verfasserin |4 aut | |
| 700 | 1 | |a Karaca, Gökhan |e verfasserin |4 aut | |
| 700 | 1 | |a Haberal Can, Ilknur |e verfasserin |4 aut | |
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